Cancer Weekly
Susan Hasty, Publisher
Table of Contents . . . August 24th, 2004
Non-Subscriber - Summaries OnlyRelated Areas: Other Issues in Cancer Weekly | Other Publications
Cancer Vaccine - Peptide vaccination augments antitumor response, but efficacy is limited
Colon Cancer - Aspirin-induced gene expression changes identified
Gastric Cancer - Gene expression-based classification model devised
Gastroenterology - Bevacizumab diminishes the vascularity of colorectal cancer
Pediatric Cancer - HCV-associated liver disease in young cancer survivors shadows adult illness
Acute Lymphoblastic Leukemia - DNA microarrays useful for pediatric ALL classification
Anorexia - Ghrelin increases energy intake in cancer patients with impaired appetite
Antibody Development - Dyax licenses its antibody phage display libraries for antibody development
Awards - Cancer-focused biologics company named among top 15 emerging biotech companies
Awards - Pharmaceuticals company named among top 15 biotech companies of 2004
Bone Marrow Transplantation - Simple "pocket calculator" method enables busulfan dose adjustment in pre-BMT
Brain Cancer - 3-D irradiation of brain cancer in children can spare cognitive functions
Brain Cancer - 3-D irradiation of brain tumors in children spares IQ, memory
Brain Cancer - Clusters of alterations on PIK3CA gene found in brain cancers
Brain Tumor - Nutritional rehabilitation may help growth in pediatric brain cancer patients
Brain Tumor - Permanently implanted device used for intratumoral chemotherapy in rat brain
Breast Cancer - Adherence to treatment guidelines improves early breast cancer survival
Breast Cancer - Cell type-specific responses to chemotherapy determined
Breast Cancer - Data indicate an adjuvant chemotherapy has low risk of cardiotoxicity
Breast Cancer - Enrollment completed in phase II trial of Theratope for breast cancer
Breast Cancer - FDA clears mammography diagnostic workstation
Breast Cancer - Few U.S. surgeons doing enough operations to optimize outcomes
Breast Cancer - HER2 status determines trastuzumab therapeutic response
Breast Cancer - Insulin modulates MCF-7 cell response to paclitaxel
Breast Cancer - Interleukin-12 targets breast tumor proliferation, metastasis, and angiogenesis
Breast Cancer - Liposomal-encapsulated doxorubicin and paclitaxel regimen effective
Breast Cancer - Local cytokine gene delivery + chemotherapy tested in mouse model of metastasis
Breast Cancer - Modeling breast-screening study data shows mammography, breast exam benefits
Breast Cancer - Study: Low 'good' cholesterol might signal breast cancer risk
Breast Cancer - Synthetic polypeptide against CXCR4 inhibits breast cancer metastasis
Breast Cancer - p53 mutation more prevalent in African American women
Business & Finance - Cancer-focused genetics company reports second quarter 2004 financial results
Business & Finance - Celera reports improved results for Q4 and FY2004
Business & Finance - Cytoskeleton-focused company reports 12% increase over Q2 last year
Business & Finance - Drug firm reports $0.04 per share income, plans for pancreatic cancer study
Business & Finance - GVAX maker reports net loss of $26.0 million for the quarter
Business & Finance - Pharmaceutical firm reports loss of $0.18 per share
Business & Finance - Record second quarter net income reported by cancer-focused genetics company
Business Update - Biotech company signs agreement with prostate center, announces financing update
Business Update - Diagnostic testing company announces financial results
Business Update - Public life sciences company offers goals, names personnel, releases study
Cancer Diagnostics - Cancer detection kit fuses molecular diagnostics, nanotechnology
Cancer Diagnostics - Fixative and storage time can alter tissue EGFR expression
Cancer Genetics - Founder mutation in Afrikaner families associated with BRCA1 mutations
Cancer Genetics - High rate of founder BRCA1 mutations occur in Polish breast cancer families
Cancer Growth Factor - VEGF inhibitors execute robust changes in a number of tumor growth systems
Cancer Immunotherapy - Painted lymphocytes are driven to vascularized solid tumors
Cancer Research - CombiMatrix announces array for 67 newly identified cancer genes
Cancer Risk Factors - Alterations in vitamin D receptor gene increase prostate, breast cancer risk
Cancer Therapy - Biopharmaceutical company initiates chemotherapy combination study for KRX-0401
Cancer Therapy - Gemzar combination therapy for ovarian cancer wins European approval
Cancer Therapy - Investigational antitumor agent clinical trial started
Cancer Therapy - M. D. Anderson Cancer Center licensed rights to preclinical cancer therapeutics
Cancer Therapy - NK4 suppresses liver metastasis in murine colon cancer models
Cancer Therapy - Novel scFv antibody targets MRP1 in malignant cells
Cancer Therapy - PEP005 shows highly selective activity against acute myelogenous leukemia
Cancer Therapy - Plans for patented cancer therapy manufacturing facility in Poland approved
Cancer Therapy - Proteasome inhibitors encouraging as anticancer drugs
Cancer Therapy - Second patent issued for delivery of brachytherapy for spinal metastases
Cancer Therapy - Shire BioChem, Inc., sells rights to anticancer agent
Cancer Therapy - Two-pronged attack targeting EGF receptor hinders cancer cell growth
Cancer Vaccine - Complement receptor-related gene tumor vaccine induces antitumor activity
Cancer Vaccine - Dendritic cells targeted with antigen-containing liposomes
Cancer Vaccine - Enzymes expressed by dendritic cells hydrolyze tumor-associated antigen
Cancer Vaccine - Hybrids of tumor and dendritic cells induce immune responses in melanoma
Cancer Vaccine - Irradiation of tumors promotes vaccine-mediated T-cell killing
Cancer Vaccine - Pre-designated peptides used in individualized peptide vaccination regimen
Cancer Vaccine - Therapeutic idiotype vaccines in B lymphoproliferative diseases reviewed
Cancer Vaccine - Trojan antigen peptide vaccines induce antitumor immune responses
Candida Infection - Length of intensive care independent risk factor for Candida infection
Cervical Cancer - Initiation of E6/E7 oncogene expression differs among HPV-16 variants
Cervical Cancer - PTEN mutation associated with HPV-negative adenocarcinoma of uterine cervix
Chemotherapy - FDA grants 510k clearance for Morpheus CT PICC
Chemotherapy - Researchers study influence of 2-chlorodeoxyadeno sine on human erythrocytes
Clinical Trial - Biosciences company reports financial results
Clinical Trials - Phase 2 clinical trial initiated for SGN-15 biomarker to set dosage
Collaborations - Cancer-targeting technology licensed to Epeius
Collaborations - U.S. approves deal to license cancer drugs from Cuban institute
Colon Cancer - Bile derivatives induce apoptosis in HT-29 human colon cancer cells
Colon Cancer - Cellular growth characteristics not affected by Adenylate kinase I
Colon Cancer - Deprivation, comorbidity, survival studied in patients with colorectal cancer
Colon Cancer Screening - Patients face long wait for colonoscopies
Colorectal Cancer - $5M milestone payment issued for development of Erbitux outside of North America
Colorectal Cancer - DNA microarray analyzes the effects of vitamin D on genes in colon cancer
Colorectal Cancer - Thymidine phosphorylase activity predicts of 5'-dFUR sensitivity
Complementary and Alternative Medicine - Green tea suppresses several growth pathways in endothelial cells
Corticosteroids - GeoPharma acquires rights to market Prednisone
Coxsackievirus - Coxsackievirus B3-caused apoptosis is via VP2 and Siva protein interactions
Dental Health - Chinese FDA approves clinical trials of new dental product
Dermatology - Approval gained for sun-induced, precancerous skin condition treatment
Diabetes - Cancer and diabetes services available on Phelophepa Healthcare Train in Africa
Diagnostic Imaging - Preoperative images prognosticate outcomes after liver cancer resection
Diagnostics - Real-time PCR quantifies intestinal bacterial populations
Diet & Nutrition - Study links high carbohydrate diet to increased breast cancer risk
Disease Associations - Cervical cancer rates in Vietnam linked to war-time movement of soldiers
Distribution Agreement - Elekta wins major oncology contract with GPO
Drug Development - Anti-tumor mechanisms of Mana-Hox characterized
Drug Development - Companies enter expanded agreement to develop, manufacture aptamers
Drug Development - Human CXCR4 promoter is a unique target for renal cell carcinoma gene therapy
Drug Development - Novel taxoid mimics activity against breast cancer cells
Drug Resistance - Bcl-2 can be targeted for cancer eradication
Endometrial Cancer - Estrogen receptor modulator regulates proteins in endometrial cancer cells
Epigenetics - Malignant cancer cells generate mice through cloning
Esophageal Cancer - New test gives hope for early diagnosis of esophageal cancer
Eye Cancer - Patients use new radiation-blocking glasses
Finance - Biopharmaceutical company announces third quarter financial results
Finance - Biopharmaceutical compound developer reports second quarter 2004 results
Finance - Canadian specialty pharmaceutical company reports financial results
Finance - Cell-imaging company reports positive second-quarter results
Finance - Diagnostics company announces record 48% increase in second quarter revenues
Finance - Gene-expression company sees revenues drop in second quarter
Finance - Men's health company reports Q2 loss of $4.5 million
Finance - Oncology-focused company reports financial results for second quarter 2004
Finance - Regeneration-focused drugmaker reports improved Q2 results
Finance - ThinPrep maker reports Q2 revenue growth of 30%
Finance - U.K. cancer group ups spending this year by 20 billion pounds
Fitness - Some exercise programs have lasting effects
Follicular Lymphoma - Prolonged rituximab regimen superior to standard treatment
Funding - Society awards $9 million in grants for leukemia, lymphona, myeloma research
Gastric Cancer - Genes affected by endocrine disruption vary with age
Gastroenterology - NK4 gene transfer stops the dissemination of gallbladder cancer
Gene Transfer - Adenovirus-mediated mda-7 gene therapy sensitizes lung tumors to radiation
Genome Maps - High-resolution comparative map of canine Chromosome 5q14.3-q33 constructed
Genomics and Genetics - Tumor suppressor RASSF1 regulates tubulin polymerization, genomic stability
Glottic Cancer - Voice optimization after endoscopic partial laryngectomy reviewed
HIV/AIDS Research - Indinavir is only HIV-1 proteinase inhibitor that inhibits HTLV-1 proteinase
HIV/AIDS-Related Cancer - IL-8 gene promoter polymorphism associated with risk of AIDS-related KS
HTLV-I Infection - Low prevalence of HTLV-I does not support screening blood donors in Lebanon
Head and Neck Cancer - Conditionally replicating adenovirus locates EBV-positive nasopharyngeal cancer
Head and Neck Cancer - IMRT effective in patients with metallic dental work
Head and Neck Cancer - The chemokine system SDF-1/CXCR4 influences squamous cell carcinoma invasion
Heart Disease - Two missense mutations in ABCA1 cause severe autosomal recessive HDL deficiency
Heart Disease & Cancer - Intervention trials needed to assess dietary patterns protecting against cancer
Helicobacter Pylori - Basophils infiltrate human gastric mucosa at sites of H. pylori infection
Herpesvirus - HHV-8-specific antibodies detected in HSCT recipients by peptide-based EIA
Herpesvirus Infection - KS associated with high pretransplant prevalence of HHV-8 among Africans
Hormone Replacement Therapy - WHI conclusions on HRT-associated endometrial cancer risk questioned
Imaging - Healthcare purchasing organization signs agreements for imaging technology
Immunology - DNA vaccine targets human papillomavirus type 16 E6 or E7 oncoprotein
Immunology - Interleukin-18 mutant gene transfer activates antitumor immunity
Immunotherapy - Company announces new manufacturing and supply agreement with GSK Biologicals
Kaposi Sarcoma-Associated Herpesvirus - KSHV infection can predispose cells to malignant transformation
Kidney Disease - Treatment also reduces related cardiovascular ailments
Legal Issues - Device company provides update on SEC investigation
Legal Issues - Doctors concerned over biased experts in asbestos lawsuits
Leukemia - Outcome for acute lymphoblastic leukemia linked to gene expression patterns
Leukemia - Protein loss plays role in acute T-cell leukemia
Liver Cancer - Small interfering RNA urokinase silencing halts hepatocellular carcinoma
Liver Cancer - TT virus-derived apoptosis-inducing protein guides hepatic pathogenicity
Liver Cancer - Viral DNA recombination improves transgene expression in liver tumor cells
Lung Cancer - ADAM9 overexpression correlates with brain metastasis in NSCLC
Lung Cancer - Advexin cancer therapy highlighted in CancerWise online publication
Lung Cancer - PCR detects genetic abnormalities in lung cancer and respiratory patients
Lung Cancer - Positive endorsement granted by FDA panel for Alimta for lung cancer
Lung Cancer - Radiofrequency ablation safe and feasible for eradicating lung tumors
Lymphocytic Leukemia - MaxCyte GT cell loading system contributes to lymphocytic leukemia trial
Lymphoma - Overexpressed GD3 synthase boosts apoptosis in vascular endothelial cells
Lymphoma - Preschool bolsters early immunity, reduces risk of young adult Hodgkin disease
Malignant Mesothelioma - SV40 could favor the survival of potentially neoplastic cells
Medical Devices - First 1.5 Tesla open bore MRI introduced by medical technologies company
Medical Devices - Oncology support system introduced at medical physicists meeting
Medical Equipment - Medical imaging company signs distribution agreement with software developer
Melanoma - Abstract presented on the use of peptide vaccine for melanoma
Melanoma - PET diagnosis could affect future standard of care for deadliest skin cancer
Melanoma - The melanoma inhibitory activity promoter guides suicide gene therapy
Mergers & Acquisitions - Biotech company completes acquisition of AltaGen Biosciences
Mergers & Acquisitions - Chromos completes acquisition
Mesothelioma Vaccine - Apoptotic cell-pulsed dendritic cells elicit T cells against mesothelioma
Molecular Biology - Interleukin-1beta is a potent regulator of tumor angiogenesis
Multiple Myeloma - Hematological cancers reflect angiogenic heterogeneity
Non-Hodgkin Lymphoma - Analysis of alveolar B lymphocytes contributes to diagnosis of lymphoma
Non-Hodgkin Lymphoma - Rituximab/saporin-S6 conjugate shows promise for treatment
Oligodendroglioma - Utility of immunohistochemistry in differential diagnosis determined
Oncogenes - Scientists unravel the drama of a decade of cancer research
Oncogenesis - Mcl-1 gene knockdown stimulates lymphoma cell apoptosis
Oncogenesis - Metastatic non-small-cell lung cancers overexpress the SKP2 gene
Oncology - A novel mouse model will better depict carcinoembryonic antigen-based therapy
Oncology - Nucleosomes from dying tumor cells promote angiogenesis
Oncology - Overexpressed PDZK1 correlates with multiple myeloma drug resistance
Oral Cancer - Researchers discover racial disparities in cancer treatment and survival
Ovarian Cancer - Differentially expressed genes in SEOC may serve as biomarkers, targets
Ovarian Cancer - Immunologic factors may help identify patients at risk for poor outcome
Ovarian Cancer - Some ovarian tumors can originate from endometrioid tissue
Pancreatic Cancer - TGF-beta expression may not have prognostic significance in pancreatic cancer
Papillomavirus - Human papillomavirus type 16 most prevalent variant in area of Central Brazil
Papillomavirus - Reflex HPV DNA testing not useful for cytologic diagnoses of LSIL or AGC-NOS
Pediatric Dermatology - Vasculogenesis is the primary growth mechanism of infantile hemangioma
Personnel - Biopharmaceutical company announces executive appointments
Personnel - Oncology-focused biopharma makes four appointments to board
Personnel - Pharma company appoints chief financial officer
Prostate Cancer - Gene expression profiling reveals novel estramustine phosphate targets
Prostate Cancer - Multimedia program cuts cancer alarm
Prostate Cancer - PSMA overexpression may be disease marker
Prostate Cancer - Prolactin-inducible protein expression elevated in prostate carcinomas
Prostate Cancer - Prostate cancer research campaign restructures
Prostate Cancer - Scientists find common virus in human prostate tissue
Prostate Cancer - Study: Combining radiation modalities increases prostate cancer cure rates
Prostate Cancer - eNOS prevents TRAIL-induced apoptosis in prostate cancer cells, study shows
Proteomics - Interferon-inducible protein-10 needs CXCR3 for angiostatic activity
Radiation Oncology - Medical physicists present on image-guided radiation therapy
Recombinant Research - Combination gene therapy staunches melanoma growth and metastasis
Reimbursement - Reductions in Medicare payment for drugs could impact continuum of cancer care
Renal Cell Carcinoma - Classification model derived from gene expression data
Retroviral Research - HTLV-1 budding requires both Nedd4 and Tsg101
Retrovirology - Full-length HTLV-I genome from MT-2 cells constructed via overlapping PCR
Sexual & Reproductive Health - HPV and chlamydia/gonorrhea testing study data presented at annual meeting
Skin Cancer - p53 mutations common in HPV type 38-positive non-melanoma skin cancers
Solid Tumors - Collaboration finalizes cancer gene therapy agreement
Stem Cell Research - Agreement renewed to supply technology for detecting tumor cells in blood
Stem Cell Research - New approach toward immortalization of hepatic progenitor cells suggested
Stem Cell Transplantation - ASCT not superior to standard chemotherapy in primary refractory Hodgkin disease
Stem Cell Transplantation - IL-2-incubated SC and IL-2 associated with rapidly reversible toxicity in NHL
Tobacco Use - Hawaii governor says cigarette campaign ruins island image
Transcription - HNF1, HNF4, and the viral X protein regulate hepatitis B virus promoters
Transplant Medicine - Octogenarian livers compromise the survival of HCV-positive graft recipients
Tumor Suppression - A common catechin blocks angiogenesis in tumor models
Tumor Therapy - Exclusive rights gained to develop ATTACK agent BC1-IL12
Tumorigenesis - Suppressed Bcl-X-L blocks the tumorigenic potential of oncogenic enzyme
Uterine Cancer - Selective expression of K+ channel subunit genes involved in cancer cell growth
Vaccine Vector - Listeria monocytogenes is effective vaccine vector
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