Published in Cancer Weekly, August 24th, 2004
"One strategy for improving selectivity of gene therapy is the use of a replication-activated adenovirus vector that mediates transgene expression specifically in tumor cells through homologous recombination of viral genomes. In this study, we compared replication-activated adenovirus containing inverted repeats (Ad.IR-BG) with IR-deficient virus (Ad.BG) for selective gene expression in hepatocellular carcinoma and colon carcinoma metastases in the liver," researchers in the United States report.
"We found that Ad.IR-BG conferred specific gene expression in both carcinoma...
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