Liver Cancer
Viral DNA recombination improves transgene expression in liver tumor cells
Published in Cancer Weekly, August 24th, 2004
"One strategy for improving selectivity of gene therapy is the use of a replication-activated adenovirus vector that mediates transgene expression specifically in tumor cells through homologous recombination of viral genomes. In this study, we compared replication-activated adenovirus containing inverted repeats (Ad.IR-BG) with IR-deficient virus (Ad.BG) for selective gene expression in hepatocellular carcinoma and colon carcinoma metastases in the liver," researchers in the United States report.
"We found that Ad.IR-BG conferred specific gene expression in both carcinoma...
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Source: Cancer Weekly (2004-08-24)
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