Colon Cancer

Aspirin-induced gene expression changes identified

Published in Cancer Weekly, August 24th, 2004

Aspirin-induced changes in gene expression have been identified in colon tumor cells.

"Aspirin and other non-steroidal anti-inflammatory drugs show efficacy in the prevention of colon cancer," scientists in the Netherlands explained. However, the "mechanism by which they do this is unclear."

In a recent study, J.C.H. Hardwick and colleagues at the University of Amsterdam "used a commercially available DNA microarray" to examine "changes in gene expression in 1,176 cancer related genes in the HT29 colon cancer cell line induced by aspirin."

"Overall we find more genes that are significantly induced than are repressed," the...

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Source: Cancer Weekly (2004-08-24)

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