Cancer Weekly
Susan Hasty, Publisher
Table of Contents . . . August 31st, 2004
Non-Subscriber - Summaries OnlyRelated Areas: Other Issues in Cancer Weekly | Other Publications
Breast Cancer Vaccine - Tamoxifen and soluble tumor-associated antigens suppress breast cancer
Cancer Therapy - Pironetin selectively targets alpha-tubulin Lys352
Cancer Vaccine - Mesothelin is new target for immunotherapy of mesotheliomas
Lung Cancer - Protein expression profiles useful in diagnosis
Oral Cancer - Oral cancer epidemic expected due to use of betel quid substitutes
Acute Myeloid Leukemia - AML-associated mutant inhibits differentiation of myeloid/erythroid stem cells
Amyotrophic Lateral Sclerosis - New biomarker study to identify unique metabolic signatures for ALS
Anemia - Aranesp receives positive regulatory opinion for extended dosing in E.U.
Angiogenesis - BNO69 angiogenesis gene discovery published in scientific journal
Antioxidants - Heme oxygenase attenuates the effects of pyrrolidinedithiocarbamate
Antioxidants - Research confirms cranberry is one of the best sources of antioxidants
Antisense Technology - Antisense RNA staunches glioma angiogenesis and growth
Antitumor Agents - Levan polysaccharides have strong antitumor activity
Arterial Thromboembolism - Systemic lupus erythematosus patients are at high risk for thromboembolism
Asbestos Exposure - Asbestos-exposure prevention is essential to prevent death, disease
Asbestos-Related Cancer - Asbestos ban in Italy needs enforcement to reverse related cancers
Bioinformatics - Comparative metaprofiling shows cancers share common transcriptional profiles
Blood Cancers - U.S. communities to raise money in September for blood cancer research
Brain Cancer - Immune vaccine followed by chemotherapy slows incurable brain tumors
Breast Cancer - HER-2 amplification can be acquired with breast cancer progression
Breast Cancer - Bcl-2 antisense oligodeoxynucleotide chemosensitizes breast carcinoma cells
Breast Cancer - HER2 expression in metastases determined
Breast Cancer - Indole-3-carbinol augments IFN responsiveness in breast tumor cells
Breast Cancer - LMWH as thromboembolic prophylaxis associated with postoperative hematoma
Breast Cancer - MIN-R EV mammography film wins R&D 100 Award
Breast Cancer - Murine study supports hypothesis that leptin may play role in tumorigenesis
Breast Cancer - New report says black women more likely to have deadly breast cancer tumors
Breast Cancer - Orphan drug designation granted from U.S. FDA for Efaproxyn
Breast Cancer - Telomere crisis is crucial stage in development of breast cancer
Breast Cancer - Upregulation of sst2 gene expression appears to indicate better prognosis
Breast Cancer - Utility of CISH in detecting HER-2/neu amplification evaluated
Breast Cancer - p53(Arg72Pro) polymorphism may be associated with ER+ risk in Japanese women
Breast Cancer Risk Factor - Link between dairy products and risk of breast cancer is weak
Breast Cancer Vaccine - Farnesyl transferase inhibitors show promise as therapies for breast cancer
Breast Cancer Vaccine - Peptides inducing immune responses in breast cancer patients identified
Business & Finance - Company reports strong Cialis sales, updates second quarter
Business & Finance - Life sciences company reports on second quarter 2004 results
Business & Finance - LymphoStat-B maker reports losses, milestones in Q2 2004
Business & Finance - Medical oncology device company announces financial results
Business & Finance - Pharma company reports second quarter 2004 results
Business & Finance - Radiation therapy provider reports second quarter 2004 financial results
Business Update - Chemoproteomics-based drug firm secures $8 million in extension of Series B financing
Business Update - Hospitals join forces for York County cancer center
Cancer Care - First edition of NCCN Drugs and Biologics Compendium to be released October 1
Cancer Epidemiology - Alabama counties with highest incidence of head and neck cancer identified
Cancer Immunotherapy - Lentiviral transfection of dendritic cells upregulates alloreactive T cells
Cancer Research - Amplification of Mdmx directly contributes to tumor formation
Cancer Research - Immunoconjugates improve targeting of photosensitizers
Cancer Research - Levels of pH and oxygenation affect tumor sensitivity to freezing
Cancer Research - Tumor fluorescence is detected with a two-photon optical fiber probe
Cancer Therapy - Antibody-targeted radiation cancer therapy reviewed
Cancer Therapy - Biotechnology company and ViroTarg sign anticancer license agreement
Cancer Therapy - Copper chelation staunches tumor vessel formation
Cancer Therapy - Independent laboratory and Merck & Co., Inc., sign oncology research partnership
Cancer Therapy - Pharma company announces publication of study examining Talabostat
Cancer Therapy - Pluronic polymer-bound doxorubicin effective in phase I trial
Cancer Therapy - Positive data reported at ASCO on T-cell-guided therapy
Cancer Therapy - Promising families of drugs combat the spread of tumors in different ways
Cancer Therapy - Small-animal imaging gives cancer clues
Cancer Therapy - Two phase I studies of HSP90 inhibitor CNF1010 begin
Cancer Vaccine - Antigen-loading strategies of dendritic cells for cancer vaccines compared
Cancer Vaccine - CD4+ responses identified in patient vaccinated with NY-ESO-1
Cancer Vaccine - Epithelial cancer-related antigens applicable for peptide-based immunotherapy
Cancer Vaccine - Exosomes from plasmacytoma cells show promise as tumor vaccine
Cancer Vaccine - Monoclonal antibodies recognize idiotypic immunoglobulins of lymphoma cells
Cancer Vaccine - Thymus-leukemia antigen acts as tumor-specific antigen
Cancer Vaccine - Viral chemokine fusions trigger antitumor immunity independent of chemotaxis
Carcinogenesis - Fumonisin B-1 encourages liver disease and liver cancer formation
Carcinogenesis - Sulforaphane modulates genes linked to cancer formation
Cell Biology - Pentraxin interactions with fibroblast growth factor stall angiogenesis
Cervical Cancer - HPV DNA subtype is prognostic factor in early stage disease
Cervical Cancer - Importance of HPV testing highlighted at meeting
Cervical Cancer - Laminin-5 gamma 2 chain expression facilitates detection of invasive lesions
Cervical Cancer - Mechanism described by which POU transcription factor represses growth in vitro
Cervical Cancer - Smoking, number of sex partners are epigenetic risk factors in NE Thailand
Chronic Myelogenous Leukemia - Child with atypical CML treated successfully with imatinib mesylate
Collaborations - CompuCyte, university announce program to validate tumor-fighting compounds
Collaborations - University signs deal for cancer gene therapy
Colon Cancer - CRE-decoy oligonucleotides and chemotherapy reduce colorectal cancer growth
Colon Cancer - Clinic's participation in colon cancer drug study provides access to new therapy
Colon Cancer - New colorectal cancer test information published
Colon Cancer - Patient enrollment complete for phase I study for colorectal cancer
Colon Cancer - Triplex-forming oligonucleotides halt colon carcinoma growth in mice
Diabetes Survival & Mortality - Diabetes increases cancer mortality risk for some cancer types
Diagnostic Imaging - The glucose tracer FDG can't define breast cancer biology on PET
Diagnostics - Consensus opinion for mammography recalls reduces technicians' stress
Diagnostics - GTx collaborates to develop a diagnostic test to detect high-grade PIN
Diagnostics - Proteomics company files for patent, continues validation of NuroPro
Diet and Nutrition - Soybean protein diet protects against methotrexate toxicity
Disease Associations - New data continues to link hepatitis C virus with non-Hodgkin's lymphoma
Drug Delivery - Homing peptide complements the effects of antiangiogenic therapy in tumors
Drug Delivery - Positive results reported: Electroporation-enabled DNA delivery sans anesthesia
Drug Development - Cross-reactive antibody explores the significance of VEGF receptor in cancer
Drug Development - Gene expression patterns in leukemia cells linked to treatment outcome
Drug Development - GlaxoSmithKline to terminate topotecan agreement
Drug Development - Type I receptor kinase inhibitors block cellular TGF-beta signaling
Drug Resistance - Down-regulated survivin sensitizes human melanoma cells to topotecan
End-Stage Renal Failure - Pentoxifylline improves hemoglobin in ESRD rh-Epo-resistant anemia patients
Endocrinology - Androgen-induced stimulation of prostate cancer requires estrogen receptor beta
Endocrinology - Vaginal gene expression after neonatal DES exposure characterized
Endometrial Cancer - Some hormone therapy options can be considered after endometrial cancer
Finance - Antibody maker completes round of private financing
Finance - Biopharmaceutical company reports increase in fourth quarter revenue
Finance - Cancer detection-focused company announces second quarter 2004 results
Finance - Cancer therapeutics company reports second quarter financial results
Finance - Cancer-focused biotech reports net loss for Q2, appoints new director to board
Finance - Cancer-focused company announces third quarter net earnings rise of 32%
Finance - DOBI Medical International completes $5.16 million private placement
Finance - Drugmaker provides Q2 update, reports net loss
Finance - Genomics company reports productive quarter despite increased net losses
Finance - Given Imaging reports first profitable quarter
Finance - Imaging/diagnostics company reports increased revenues in Q3
Finance - Nutritional supplements provider reports earnings
Finance - Oncology-focused biopharma reports record product revenues Q2 2004
Finance - Pharma company announces second quarter 2004 financial results
Finance - Pharmaceutical company reports second quarter results
Finance - Scientists seal $1 million from NASA to put stem cells in space
Fungal Infection - New antifungal agents have potential role in prophylaxis
Gastric Cancer - B7-1 gene transduction enhances immune response to metastatic tumor cells
Gastric Cancer - Broccoli consumption fails to result in low prevalence of CAG in study
Gastric Cancer - Genetic changes induced by H. pylori infection characterized
Gastric Cancer - The novel cDNA DEGA may play a role in the etiology of gastric adenocarcinoma
Gene Expression - HDAC inhibitors trigger apoptosis in HPV+ cells by inducing E2F-p73 pathway
Gene Transfer - Adenoviral vector containing tumor-specific constructs target ovarian cancer
Gene Transfer - Receptor-specific polyplexes pinpoint breast cancer cells
Genetic Abnormalities - Ariol 2.0 launched as next-generation cellular imaging system
Genetic Research - Genes may be a factor when toxic defense mechanisms decline with age
Genomics - Abrin-a A chain from a synthesized gene is catalytically and functionally active
Genomics - PRDM5 gene is silenced in human cancers and has growth-suppressive activities
Genomics - Sensitive assays combine to measure genetic damage and repair
Gynecologic Cancer - The nucleotide analog Fara-A inhibits angiogenic protein in ovarian cancer
Gynecology - Immunohistochemical staining helps diagnose endometrial Arias-Stella reaction
Head and Neck Cancer - Leech therapy can save previously unsalvageable tissue transplants
Head and Neck Cancer - Public lacks important knowledge about oral, head, neck cancer
Healthcare Coverage - GLIADEL Wafer assigned new DRG designation
Helicobacter Pylori - Body's own defense against H. pylori discovered
Hematology - Fanconi anemia C gene product regulates differentiation and inflammation genes
Hepatocellular Carcinoma - Specificity of hepatocyte paraffin 1 determined
Hospice Care - After 48 years, nuns will no longer run Parma hospice
Human Papillomavirus - Pathogenic mechanisms of small cell carcinomas of uterine cervix vary
Hyperparathyroidism - Mimpara receives positive regulatory opinion for approval in Europe
Immunology - Interferons and steroids modulate cytokine-induced IL-8 production
Immunology - Stress activation boosts the immunogenicity of tumor cells
Information Technology - Scientists at Canada's Robarts Research Institute model functioning human organs
Intercellular - Lycopene fails to inhibit growth in advanced, metastatic prostate cancers
Kaposi Sarcoma-Associated Herpesvirus - KSHV evolved a unique tactic for its stable maintenance
Leukemia - Cell loading system used in phase I/II gene therapy trial for leukemia
Leukemia - Enrollment complete for phase I/II trial of StemEx
Leukemia - Gene expression pattern may predict behavior of leukemia
Leukemia - Leukemia stem cells identified
Leukemia - Recent advances in childhood acute lymphoblastic leukemia are reported
Leukemia - There is gene expression discordance within promyelocytic leukemia cells
Lung Cancer - D-Light AF Bronchoscopy System available for early detection of lung cancer
Lung Cancer - Productivity tools complement computed tomography in lung cancer detection
Lymphoma - IL-6 levels and genotype are associated with risk of Hodgkin lymphoma
Lymphoma - Murine xenograft model of mycosis fungoides developed
Malignant Glioma - IL13-PE38QQR study commences in malignant glioma patient at initial diagnosis
Medical Devices - Imaging software company signs agreement for virtual colonoscopy applications
Medical Devices - Mexico approves use of high-intensity ultrasound device to treat prostate cancer
Medical Equipment - Software tools being developed for image-guided radiation therapy
Medical Equipment - State University of New York reports on infrared imaging to detect breast cancer
Melanoma - Anti-MAGE antibody B57 not suitable for differential diagnosis
Melanoma Vaccine - Efficacy of melanoma vaccines enhanced in the absence of B lymphocytes
Metastasis - Biologist links presence of protein to spread of cancerous cells
Metastasis - The carboxyl-terminal half of ADAMTS-1 diminishes metastatic potential
Molecular Biology - Emory researchers map structure of anticancer molecule
Molecular Therapeutics - NF-kappa B p65 subunit is target for radiation sensitization of cancer cells
Multiple Myeloma - Over-expression of Bcl-X-L results in lymphoproliferative disease, malignancies
Nanomedicine - Report: Nanomedicine brings fresh hope to the medical world
Nasopharyngeal Cancer - Aggressive treatment best for nasopharyngeal cancer
Neovascularization - Phage screening studies provide guidance for tumor targeting
Neurology - CysLT1 distribution in brain trauma and/or cancer determined
Neuroscience - Nucleus-centrosome coupling defects alter migration defects in lissencephaly
Non-Hodgkin Lymphoma - Anti-CD20 fusion protein shows promise in anti-NHL PRIT
Non-Small Cell Lung Cancer - Genentech and partner announce NDA completion for Tarceva
Oncology - Combined methods define the translocations of mixed-lineage leukemia
Oncology - Disruptions of the p53-p21/WAF1 pathway alter liver cancer progression
Oncology - Expression of cell cycle-related gene products in PVNS characterized
Oncology - Tumor cells that secrete interleukin-13 have diminished tumorigenicity
Oral Cancer - Do teeth whiteners lead to oral cancer?
Oral Cancer - Oral cancer study patients provide accurate self-reported smoking habits
Orthopedics - Expression of osteogenic factors may be associated with osteoinductivity
Ovarian Cancer - Maintaining normality, support are central care issues in chemotherapy
Ovarian Cancer - Sensitivity, specificity of MS-obtained proteomic diagnostic patterns compared
Ovarian Tumors - Gonadotropin levels higher in cancer tumor fluid than other tumor types
Personnel - Biopharmaceutical company announces new member of board of directors
Personnel - Cerus appoints William J. Dawson as vice president, finance and CFO
Personnel - Chemophase maker names Daniel Von Hoff, MD, to scientific advisory board
Personnel - Company specializing in single molecule DNA analysis appoints board members
Personnel - Drexel neuroscience faculty to move to Cooper University Hospital
Personnel - Former FDA executive to lead AustCancer development program
Pharmaceutical & Drug Development - DNA minor groove binders potential antitumor and antimicrobial agents
Pharmaceutical & Drug Development - Proteasome inhibitor bortezomib novel approach for multiple myeloma treatment
Pharmacology - Maspin gene expression could be exploited as anti-cancer therapy
Phytotherapy - Phytoestrogens regulate genes in breast cancers that lack estrogen receptors
Polyomaviruses - Polyomaviruses associated with clinical tumors
Product Licensing - European patent for Vaxfectin adjuvant granted to biopharmaceutical company
Product Licensing - Hybridon licenses key VEGF patents for treatment of ocular diseases
Product Licensing - Phytomedical enters into license agreement with New York University
Prostate Cancer - Hypericum perforatum methanolic extract inhibits prostatic cancer cells
Prostate Cancer - Biopharmaceutical company provides update on DN-101 Plus Taxotere trial
Prostate Cancer - Combination of Quadramet and chemotherapy to be evaluated in new clinical trial
Prostate Cancer - New prostate cancer gene identified
Prostate Cancer - Proof-of-concept results of prostate cancer drug published in cancer journal
Prostate Cancer - Survival rates improve for some men when combination therapies used
Prostate Cancer Vaccine - Vaccine against LH-releasing fusion protein does not increase prostate cancer
Proteomics - Liquid chromatography quantitates a breast cancer resistance protein
Renal Cancer - Drugs that manage angiogenesis slow renal cell carcinoma progression
Renal Cell Cancer - Maximal apoptosis of renal cell carcinoma is nuclear factor-kappa B dependent
Renal Cell Carcinoma - EMEA grants orphan drug designation to BAY 43-9006
Smoking Ban - Law office stops allowing smoking after health department warning
Smoking Ban - Restaurants want flexible smoking rules
Smoking Ban - Statewide smoking ban discussed in Wyoming
Smoking Cessation - Medicaid help proposed to assist smokers, chewers to quit
Stem Cell Transplanation - Survival benefit for patients with poor-risk CLL receiving sequential HDT
Stem Cell Transplantation - Long-term survival after BMT for SAA dependent on several factors
Surgical Tools - Hyperspectral imaging endoscope a new tool for noninvasive cancer detection
Survival & Mortality - Underlying cause of respiratory disease-associated deaths underestimated
Transfection - Herpes simplex virus type 1 can infect cells via non-HSV-specific receptors
Transplant Medicine - Partial nephrectomy used to treat RCC arising in a live donor transplant kidney
Tumorigenesis - Akt mediates angiogenesis in transformed keratinocytes
Urology - Proangiogenic growth factors share a cozy relationship with prostate cancer
Vector Development - Recombinant bispecific antibodies guide adenoviruses to select tumor cells
Viral Vector - Herpes simplex virus vectors create transgene persistence in motor neurons
Vulvar Cancer - Immunostaining for p16 distinguishes between HPV/non-HPV vulvar carcinomas
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