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Genetic Research

Genes may be a factor when toxic defense mechanisms decline with age

Published in Cancer Weekly, August 31st, 2004

Researchers in Germany have studied polymorphic metabolic susceptibility genes and longevity.

In Toxicology Letters, researchers from Germany wrote, "In order to investigate possible associations of genetic variants in genes of xenobiotic metabolism with longevity, we compared allele frequencies and genotype distributions of polymorphic genes between 205 octogenarians and a non-cancer reference group of 294 persons aged <80 years."

The researchers explained, "We analyzed common sequence variations in the cytochrome P-450 genes CYP1A1T461N, 3801 T > C and CYP1B1 V432L, and in the glutathione S-transferase genes GSTM1 (deletion), GSTT1...

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