Pharmaceutical & Drug Development
DNA minor groove binders potential antitumor and antimicrobial agents
Published in Cancer Weekly, August 31st, 2004
According to published research from Italy, "DNA minor groove binders constitute an important class of derivatives in anticancer therapy.
"Some of these compounds form noncovalent complexes with DNA (e.g., distamycin A, Hoechst 33258, and pentamidine) while others DNA-binding compounds (such as CC-1065) cause cleavages in the DNA backbone."
"In this article," P.G. Baraldi and coworkers reported, "we have reviewed the minor groove binders currently in preclinical evaluation in the last years. Diarylamidines such as DAPI, berenil, and pentamidine;...
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Source: Cancer Weekly (2004-08-31)
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