Cancer Immunotherapy
Lentiviral transfection of dendritic cells upregulates alloreactive T cells
Published in Cancer Weekly, August 31st, 2004
According to recent research from Japan, "gene-modified dendritic cells (DCs) are promising targets for cancer immunotherapy. In this study, we demonstrated that lentiviral transduction of DCs with the gp34/OX40L gene, one of the costimulatory molecules, facilitates alloreactive CD4+ T-cell response in vitro."
"We achieved a 20% to 40% efficiency of gp34/OX40L gene transfer into DCs by the lentiviral vector, and lentiviral gp34/OX40L gene transfer did not alter the surface phenotype of either immature or mature DCs, suggesting that expression of gp34/OX40L did not induce the...
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Source: Cancer Weekly (2004-08-31)
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