Cell Biology

Pentraxin interactions with fibroblast growth factor stall angiogenesis

Published in Cancer Weekly, August 31st, 2004

Pentraxin interactions with fibroblast growth factor stall angiogenesis.

"The long pentraxin PTX3 is a soluble pattern recognition receptor produced by monocytes and endothelial cells that plays a nonredundant role in inflammation. Several pathologic conditions are characterized by local production of both PTX3 and the angiogenic fibroblast growth factor-2 (FGF2). Here, solid-phase binding assays demonstrated that PTX3 binds with high affinity to FGF2 but not to a panel of cytokines and growth factors, including FGF1, FGF4, and FGF8," scientists writing in the journal Blood report.

"Accordingly, PTX3 prevented ¹²⁵I-FGF2 binding to...

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Source: Cancer Weekly (2004-08-31)

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