Colon Cancer

Triplex-forming oligonucleotides halt colon carcinoma growth in mice

Published in Cancer Weekly, August 31st, 2004

Triplex-forming oligonucleotides halt colon carcinoma growth in mice.

"We have previously shown that oligonucleotides designed to bind in triplex fashion to a specific p53 binding site homology inhibit the proliferation of colon cancer cells in vitro. The present study was designed to extend these observations in an in vivo model. HCT 116 human colon carcinoma cells were injected subcutaneously into Ncr nude mice and tumors formed at one to two weeks," investigators in the United States report.

"Tumors were injected daily for 14 days with either triplex forming oligonucleotide (Hoog 1), a scrambled Hoog 1 oligonucleotide (Hoog3) as control, or...

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Source: Cancer Weekly (2004-08-31)

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