Neoplasia
The marine product aplidine hammers proangiogenic stimuli
Published in Cancer Weekly, September 7th, 2004
"The antineoplastic compound aplidine, a new marine-derived depsipeptide, has shown preclinical activity in vitro on hematological and solid tumor cell lines. It is currently in early phase clinical trials. The exact mechanism of action of this anticancer agent still needs to be clarified," scientists writing in the British Journal of Cancer report.
"We have previously reported that aplidine blocks the secretion of the angiogenic factor vascular endothelial growth factor (VEGF) by the human leukemia cells MOLT-4, suggesting a possible effect on tumor angiogenesis. This study was...
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Source: Cancer Weekly (2004-09-07)
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