Breast Cancer Therapy

Trastuzumab-related cardiotoxicity characterized

Published in Cancer Weekly, September 7th, 2004

Trastuzumab-associated cardiotoxicity has been characterized in breast cancer patients.

"Trastuzumab (Herceptin) is a humanized monoclonal antibody that specifically targets HER2-positive breast cancer cells," scientists in Switzerland explained. "Safety data collected from pivotal trials with trastuzumab indicate that this therapy is generally well tolerated."

"However, trials of the combination of trastuzumab plus chemotherapy, and in particular chemotherapy with anthracyclines, have revealed an elevated incidence of cardiotoxicity in some patients, which was not apparent in preclinical or early clinical studies," noted T.M. Suter and colleagues at...

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Source: Cancer Weekly (2004-09-07)

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