Cancer Research

Copper-containing hydroxylapatite can retain antibiotic

Published in Cancer Weekly, September 7th, 2004

Researchers in France report on their study of the release of anthracyclines adsorbed on copper-treated hydroxylapatites.

According to R.A. Bacha and colleagues, "Anthracyclines are antibiotics widely used for the treatment of leukemia and solid tumors. Perfusion is the standard clinical administration form. Unfortunately, this does not allow treatment of gastric cancers."

The researchers reported, "A new galenic presentation, consisting of anthracyclines adsorbed onto hydroxylapatite granules, has been developed. It was found to be possible to modulate the release of the drug as a function of the pH by using copper(II) ions. At neutral pH, the drug...

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Source: Cancer Weekly (2004-09-07)

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