Breast Cancer Therapy

Anti-HER-2 mAbs synergistically kill breast tumor cells

Published in Cancer Weekly, September 28th, 2004

Anti-HER-2 monoclonal antibodies synergistically kill breast tumor cells.

"Trastuzumab (herceptin) and pertuzumab (Omnitarg, 2C4) are recombinant humanized monoclonal antibodies that target different extracellular regions of the HER-2 tyrosine kinase receptor," oncologists in Texas explained.

R. Nahta and colleagues at the M.D. Anderson Cancer Center in Houston "explored combination effects of these agents in the HER-2-overexpressing BT474 breast cancer cell line."

"Trastuzumab and 2C4 synergistically inhibited the survival of BT474 cells, in part because of increased apoptosis," test results revealed. "Trastuzumab increased...

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Source: Cancer Weekly (2004-09-28)

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