Published in Cancer Weekly, September 28th, 2004
"Mechanisms of resistance to cancer chemotherapy are poorly understood. Molecular pathways involving genes associated with inherited cancer syndromes could represent mechanisms of chemoresistance," scientists in Norway explained.
"Microarray techniques can identify simultaneous alterations in the mRNA expression of multiple genes, but identification of the exact mechanism responsible for a particular phenotype, including resistance to a specific drug, remains problematic," noted P.E. Lonning and colleagues at Haukeland University Hospital.
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