Esophageal Adenocarcinoma
Expression of LAT-1 characterized
Published in Cancer Weekly, September 28th, 2004
"The L-type amino acid transporter-1 (LAT-1) has been associated with tumor growth," oncologists in the United States explained.
"Using cDNA microarrays, overexpression of LAT-1 was found in 87.5% (7/8) of esophageal adenocarcinomas relative to 12 Barrett samples (33% metaplasia and 66% dysplasia) and was confirmed in 100% (28/28) of Barrett adenocarcinomas by quantitative reverse transcription polymerase chain reaction," in a study conducted by J. Lin and coauthors at the University of Michigan.
"Immunohistochemistry revealed LAT-1 staining in 37.5% (24/64)...
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Source: Cancer Weekly (2004-09-28)
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