Colorectal Cancer

Wif-1 overexpression linked to pathogenesis

Published in Cancer Weekly, September 28th, 2004

The Wif-1 gene may be involved in the pathogenesis of colorectal cancer.

"Using cDNA-Representational Difference Analysis," researchers in Poland found that "expression of Opg, Ctse, Krt2-4, Fut-2, 24p3 and Wif-1 genes was elevated in intestinal adenomas as compared to normal epithelial cells of Apc^Min/+ mutant mice."

"Expression of Wif-1, which encodes Wnt inhibitory factor-1 was also detected in a number of tumor cell lines of epithelial cell origin including two human colon adenocarcinoma cell lines," reported M. Cebrat and coauthors at the Polish Academy of...

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Source: Cancer Weekly (2004-09-28)

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