Adverse Drug Effects

Substance P may play role in hypersensitivity reactions induced by paclitaxel

Published in Cancer Weekly, September 28th, 2004

Substance P may play a role in hypersensitivity reactions induced by paclitaxel, suggest pharmacologists at Kyushu University, Japan.

"The role of substance P in adverse pulmonary reactions induced by an anticancer agent paclitaxel was investigated in rats and humans who undertook postoperative chemotherapy for ovarian cancer," T. Sendo and colleagues wrote in the journal Peptides.

They reported that "[i]n rats, paclitaxel caused a marked plasma extravasation and edema in lungs with a concomitant decrease in arterial partial oxygen pressure, which were reversed by an NK1 antagonist LY303870. Substance P level in rat plasma and bronchoalveolar...

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Source: Cancer Weekly (2004-09-28)

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