Gene Delivery

Outgrowth endothelial cells host gene vectors that target tumor vessels

Published in Cancer Weekly, September 28th, 2004

Outgrowth endothelial cells host gene vectors that target tumor vessels.

According to recent research from the United States, "cell-based delivery of therapeutic viruses has potential advantages over systemic viral administration, including attenuated neutralization and improved viral targeting. One of the exciting new areas of investigation is the potential ability of endothelial-lineage cells to deliver genes to the areas of neovascularization."

"In the present study, we compared two types of endothelial-lineage cells [outgrowth endothelial cells (OECs) and culture-modified mononuclear cells (CMMCs), also known as "endothelial progenitor cells"]...

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Source: Cancer Weekly (2004-09-28)

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