Glioma

Proteome analysis can predict tumor aggressiveness

Published in Cancer Weekly, September 28th, 2004

Proteome analysis can be used to predict the aggressiveness of glioma tumors.

"The biological features of gliomas, which are characterized by highly heterogeneous biological aggressiveness even in the same histological category, would be precisely described by global gene expression data at the protein level," oncologists in Japan explained.

In their study, Y. Iwadate and colleagues at Chiba University "investigated whether proteome analysis based on two-dimensional gel electrophoresis and matrix-assisted laser desorption/ionization time-of-flight mass spectrometry can identify differences in protein expression between high- and low-grade glioma...

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Source: Cancer Weekly (2004-09-28)

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