Cancer Therapy
Peloruside A tubulin binding characterized
Published in Cancer Weekly, October 5th, 2004
"Peloruside A (peloruside), a microtubule-stabilizing agent from a marine sponge, is less susceptible than paclitaxel to multidrug resistance arising from overexpression of the P-glycoprotein efflux pump and is not affected by mutations that affect the taxoid binding site of beta-tubulin," scientists in New Zealand.
"In vitro studies with purified tubulin indicate that peloruside directly induces tubulin polymerization in the absence of microtubule-associated proteins," reported T.N. Gaitanos and colleagues at the Victoria University of Wellington.
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Source: Cancer Weekly (2004-10-05)
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