Chemotherapy

Overexpressed dominant-negative FANCA helps cisplatin battle tumors

Published in Cancer Weekly, October 5th, 2004

Overexpressed dominant-negative FANCA helps cisplatin battle tumors.

"Fanconi anemia (FA) is a rare genetic disorder characterized by bone-marrow failure and cellular hypersensitivity to crosslinking agents, including cisplatin. Here, we studied the use of the FA pathway as a possible target for cancer gene therapy with the aim to sensitize tumor cells for cisplatin by interfering with the FA pathway," investigators in the Netherlands stated.

"As proof-of-principle, FA and non-FA lymphoblast-derived tumors were grown subcutaneously in SCID mice and treated with two different concentrations of cisplatin," described M. Ferrer and colleagues, VU...

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Source: Cancer Weekly (2004-10-05)

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