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Virology Vaccine

Dendritic cell vaccine protects against Friend retrovirus infection

Published in Cancer Weekly, October 12th, 2004

Vaccination with antigen-loaded, spleen-derived dendritic cells protected mice against Friend retrovirus infection.

"Antigen-loaded dendritic cells (DC) have been shown to induce specific immune responses in vivo. In the current study we used Friend virus (FV) as a model to analyze whether a DC vaccine is capable of inducing protective immunity against retroviral infections. Mice were vaccinated twice with spleen-derived DC loaded with FV antigen. All control mice that received DC without antigen developed progressive leukemia after FV challenge," scientists writing in the journal Vaccine report.

"In contrast, 5 of the 14 vaccines were...

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