Cancer Weekly

Environmental Health - Effects of Cold War nuclear tests on Idaho residents presented to panel

Environmental Health - Genotoxic effects of N-nitrosomorpholine clarified

Environmental Toxins - Genetic mutations linked to the practice of burning coal in homes in China

Enzymology - Macrophages generate cytokines that stimulate breast cancer invasion

Fundraising - Communications group sponsors Portland's Susan G. Komen Race for the Cure

Gastric Cancer - Curing Helicobacter pylori infection does not prevent all gastric cancers

Gastric Cancer - Study results validate ZNRD1 as a potential therapeutic target in gastric cancer

Gene Inhibition - Synthetic curcumin analogs curtail genes related to angiogenesis

Genomics - Genome company awarded National Human Genome Research Institute grant

Graft-Versus-Host Disease - Infliximab well tolerated/effective for steroid-resistant acute GVHD treatment

Graft-Versus-Host Disease - Monocyte/macrophage dysfunction has major role in pathophysiology of GvHD

Gynecologic Cancer - Data gathered and reported during gynecologic cancer awareness month

Gynecologic Cancers - Concurrent ovarian and endometrial cancers highlight diagnostic difficulties

Gynecologic Cancers - Study validates Sexual function-Vaginal changes Questionnaire

Gynecology - Double-modified adenovirus transfers genes to cervical cancer in vivo

HIV/AIDS-Associated Cancer - Cancer registry data useful resource for monitoring HIV-associated cancers

HIV/AIDS-Associated Lymphoma - T- and B-cell lymphoma demographics/immunology in HIV-infection characterized

Head and Neck Cancer - Amyloid precursor protein is a prognostic marker for oral carcinogenesis

Head and Neck Cancer - Curcumin regulates nuclear factor kappa B to suppress cancer cell growth

Head and Neck Cancer - History of smoking significantly reduces survival in cancer patients

Head and Neck Cancer - Immunological aspects of head and neck cancer reviewed

Healthcare Coverage - Software empowers patients to take charge of medical expenses

Hepatitis - Biotechnology company names clinical advisory board

Hepatology - Main cytochrome P450 enzymes involved in safrole 1'-hydroxylation identified

Herpesvirus - (S)-MCT prodrug inhibits HSV-1 TK-transduced osteosarcoma cell growth

Human Papillomavirus Vaccine - DNA vaccine targeting HPV type 16 oncoprotein E6 developed

Human Papillomavirus Vaccine - Human papillomavirus in cervical cancers in Mozambique genotyped

Hypertension - Pharma company expands Diovan production at Swiss manufacturing site

Imaging - Research institute opens clinical imaging research lab in Canada

Imaging - Swedish regulatory authorities to approve novel imaging drug Hexvix

Immunology - Company initiates phase III clinical trial for FavId

Immunotherapy - FDA accepts sBLA for expanded use of BEXXAR; decision expected by January 2005

Information Technology - Cancer center quality diagnostics on every physician's computer via web tool

JC Virus - JC virus agnoprotein inhibits DNA repair after DNA damage

Kaposi Sarcoma-Associated Herpesvirus - KSHV ORF57 protein interacts with REF protein and acts as RNA export factor

Keratoacanthoma - Telomerase activity and COX-2 may be potential markers for certain cancers

Legislative Issues - Survivors, physicians stress need for gynecologic cancer awareness bill

Leukemia - Arsenic could be suitable as first-line treatment in type of leukemia

Leukemia - Data demonstrates potential role for QUADRAMET in acute myeloid leukemia

Leukemia - Evidence builds for potential new cancer drug target

Leukemia Vaccine - Leukemia-derived dendritic cells become cells that stimulate T cells

Licensing Agreement - Genaissance Pharmaceuticals licenses vilazodone, an SSRI

Lung Cancer - Drug exposure may enhance in vitro invasiveness of lung cancer cell line

Lung Cancer - Genetic markers of heightened NSCLC metastasis risk identified

Lung Cancer - Novel candidate genes for systemic metastasis identified

Lung Cancer Vaccine - Peptides eliciting multiple responses in lung cancer identified

Lung Carcinoma - Peroxiredoxins seem to influence lung cancer progression

Lung Tumors - TTF-1 expression is specific for lung primary in typical and atypical carcinoids

Lymphoma - SGN-30 phase 2 clinical trial for cutaneous lymphoma initiated

Lymphoma Vaccine - EBNA1-specific CD4+ T cells are key for control of Burkitt lymphoma

Malignant Melanoma - Ceplene trial in advanced malignant melanoma fails to meet primary endpoint

Medical Devices - Noninvasive blood pressure monitoring device tested at children's hospital

Melanoma - Enrollment completed in phase III trial of Canvaxin

Melanoma - Pamidronate, zoledronate inhibit proliferation of human melanoma cells

Melanoma - U.S. FDA authorizes start of phase 2 clinical trial on melanoma vaccine

Melanoma Vaccine - Immune responses to peptide epitope in melanoma patients described

Mesothelioma - Diffuse malignant mesothelioma of the peritoneum and pleura studied

Metastases - Succinct interactions trigger interleukin-8 in invasive breast cancer

Metastasis - Molecular switch found that allows cancer cells to become mobile

Microencapsulation - pH-triggered microparticles for peptide vaccination developed

Myelodysplastic Syndromes - EMEA accepts marketing authorization application for Vidaza for review

Non-Hodgkin Lymphoma - Marqibo to be reviewed by FDA Oncologic Drugs Advisory Committee

Non-Hodgkin Lymphoma - NHL patients do not receive full dose of chemo, study shows

Obstetrics - Study: Methimazole isn't safe during pregnancy

Occupational Safety - Occupational safety institute published hazardous drug exposure report

Oncogenesis - Angiogenic restraint is lost as myeloma progresses

Oncology - Midkine promoter-driven gene therapy strikes down immortalized and tumor cells

Oncology - Pharmaceutical company announces developments in oncology program

Oncology - VEGF₁₆₅ antagonizes semaphorin 3B-initiated apoptosis in cancer cells

Oral Cancer - Saliva plays role in development of oral cancer

Osteosarcoma - Enzyme maintaining chromosome ends is linked to cancer recurrence

Osteosarcoma Model - Mechanical strain can alter tissue-factor activity in rat osteosarcoma cells

Ovarian Cancer - Chemotherapy helps women with localized disease

Ovarian Cancer - Gene amplification is one mechanism for hK6 overexpression in ovarian cancer

Ovarian Cancer - Phase II trial data on carboplatin/paclitaxel/gemcitabine regimen reported

Ovarian Tumors - Case reported of late recurrence of juvenile granulosa cell tumor of the ovary

Pain Management - Survey finds one in three Connecticut adults experience pain on a daily basis

Pancreatic Cancer - Neurobiological gene therapy company signs license agreement for enzymes

Patents - Genomics company receives international patents

Pediatric Cancer - Researchers report on professional collaboration with cancer patients, families

Pediatric Leukemia - FDA Oncologic Drugs Advisory Committee to review clofarabine

Personnel - Diversity in U.S. healthcare professions is separate, unequal, commission says

Personnel - Gene technology company appoints new member to board of directors

Personnel - Pharmaceutical company announces new personnel appointments

Personnel - Walter Singleton named vice president, clinical and regulatory affairs

Polio Vaccine - Simian virus-tainted polio vaccine does not raise childhood cancer risk

Prostate Cancer - A glass of red wine a day may keep prostate cancer away

Prostate Cancer - Combination trial to study MDX-010 with GVAX prostate cancer vaccine

Prostate Cancer - Cottonseed drug is cancer treatment booster - patient trials now planned

Prostate Cancer - Elderly African American men less likely to undergo prostate cancer screening

Prostate Cancer - Lycopene slows human prostate tumor growth in mice

Prostate Cancer - Patient enrollment commences in U.S. prostate cancer study of Modrenal

Prostate Cancer - Report on prostate cancer frames debates on treatment

Prostate Cancer - Serum PSA screens have high sensitivity in Finnish population

Prostate Cancer - Trial to assess if Zyflamend prevents prostate cancer

Prostate Cancer Vaccine - Antigen-derived peptides induce CTLs in prostate cancer patients

Prostate Cancer Vaccine - DNA vaccine elicits immune response in patients with prostate cancer

Prostate Cancer Vaccine - Gene-based therapy in prostate cancer reviewed

Proteomics - Function of S. cerevisiae Yaf9p protein clarified

Radiation Therapy - Companies partner to distribute OneDose patient dosimetry system

Rectal Cancer - Immunohistochemical markers of poor prognosis identified

Renal Cancer - SU5416 treats metastatic kidney cancer in a von Hippel-Lindau syndrome patient

Retinoblastoma - Long-term efficacy of electron beam radiotherapy determined

Skin Cancer - American Academy of Dermatology awards 2004 Shade Structure Grants

Staffing - New VISTA staffing unit offers temporary oncologist staffing

Stem Cell Research - CCR7 expression on BM-derived dendritic cells is indication of cell maturity

Stem Cell Research - Model transforms stem cells to express breast cancer estrogen receptor

Stem Cell Research - Neural progenitor cell lines inhibit tumor growth

Testicular Dysgenesis Syndrome - Hypospadias, cryptorchidism, and testicular cancer have common risk factors

Tobacco Use - The lung may act as a short-term depot for nicotine

Transplant Medicine - Interferon-gamma infusion prepares recipients for genetically modified cells

Tumor Suppression - The combretastatin OXI4503 boosts tumor vessel collapse via apoptosis

Tumor Therapy - Antisense drug targeting STAT-3 demonstrates significant antitumor activity

Virology - Genetically modified adenoviruses show promise for treating gliomas

Virology - Transfected liver cancer cells offer a new venue for exploring hepatitis B

Vulvar Cancer - Diagnosis and treatment of relatively rare gynecologic cancer discussed

Weight Loss - Researchers link citrus to weight loss, reduced heart disease and cancer