Oncology
VEGF165 antagonizes semaphorin 3B-initiated apoptosis in cancer cells
Published in Cancer Weekly, October 19th, 2004
"Semaphorin 3B (SEMA3B) is a secreted member of the semaphorin family, important in axonal guidance. We and others have shown that SEMA3B can act as a tumor suppressor by inducing apoptosis either by re-expression in tumor cells or applied as a soluble ligand. The common method of inactivation of SEMA3B is by allele loss and tumor-acquired promoter methylation," investigators in the United States report.
"We studied the mechanism of SEMA3B-induced tumor cell apoptosis and found that vascular endothelial growth factor 165 (VEG165 ) significantly decreased the...
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Source: Cancer Weekly (2004-10-19)
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