The combretastatin OXI4503 boosts tumor vessel collapse via apoptosis

"The mechanism of tumor cell killing by OX14503 was investigated by studying vascular functional and morphological changes post drug administration. Severe combined immunodeficient mice bearing MHEC5-T hemangioendothelioma were given a single dose of OX14503 at 100 mg/kg. Tumor blood flow, measured by microsphere fluorescence, was reduced by 50% at 1 hour (h), and reached a maximum level 6-24 h post drug treatments. Tumor vascular permeability, measured by Evan's blue and hemoglobin, increased significantly from 3 hr and peaked at 18 hr," scientists in Sweden report.

"The elevated...

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