Cancer Vaccine

Antitumor responses promoted by bone marrow from immunized donors

Published in Cancer Weekly, October 19th, 2004

Antitumor immune responses are augmented after adoptive transfer of bone marrow derived from donors immunized with tumor lysate-pulsed dendritic cells.

According to recent research published in the journal Biology of Blood and Marrow Transplantation, "We demonstrated previously that tumor lysate-pulsed dendritic cells (TP-DC) could mediate a specific and long-lasting antitumor immune response against a weakly immunogenic breast tumor during early lymphoid reconstitution. The purpose of this study was to examine the potential therapeutic efficacy of bone marrow transplants from TP-DC-vaccinated donors. In 2 aggressive metastatic models, bone marrow transplantation...

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Source: Cancer Weekly (2004-10-19)

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