Gene Therapy

Break repair protein endo-exonuclease is a therapeutic target for cancer

Published in Cancer Weekly, October 26th, 2004

According to a study from Canada, "DNA repair mechanisms are crucial for the maintenance of genomic stability and are emerging as potential therapeutic targets for cancer.

"In this study, we report that the endo-exonuclease, a protein involved in the recombination repair process of the DNA double-stranded break pathway, is overexpressed in a variety of cancer cells and could represent an effective target for developing anticancer drugs."

"We identify a dicationic diarylfuran, pentamidine, which has been used clinically to treat opportunistic infections and is an inhibitor of the endo-exonuclease as determined by enzyme kinetic assay," reported T.Y.K....

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Source: Cancer Weekly (2004-10-26)

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