Prostate Cancer

Novel immunotoxin shows promise in murine model

Published in Cancer Weekly, October 26th, 2004

A novel immunotoxin has produced promising results in a murine model of prostate cancer.

"Prostate-specific membrane antigen (PSMA) is a transmembrane protein that is largely restricted to prostatic epithelial cells in humans and is strongly upregulated on prostatic carcinoma cells," scientists in the United States explained. "It is also expressed on the endothelium of tumor vasculature in humans, but not on the vasculature of normal tissues."

"Expression of low levels of PSMA has also been found on non-vascular cells in several normal tissues, most prominently on the brain and kidney in humans," noted X.M. Huang and colleagues at the University of...

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Source: Cancer Weekly (2004-10-26)

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