Clear Cell Sarcoma

Gene mutations linked to poor prognosis identified

Published in Cancer Weekly, October 26th, 2004

Gene mutations linked to aggressive disease in clear cell sarcoma (CCS) have been identified.

CCS is "a very rare soft tissue sarcoma with a poor prognosis," oncologists in Japan explained. "It has become apparent through immunohistochemical, ultrastructural, and microarray analyses that CCS is a soft tissue melanocytic neoplasm."

"Alterations in the p16^INK4a/p14^ARF gene are common in malignant melanoma, which is the prototypical melanocytic neoplasm," noted T. Takahira and colleagues at Kyushu University. In a recent study, they "performed a clinicopathologic analysis and investigated p16 and cyclin D1 expression by...

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Source: Cancer Weekly (2004-10-26)

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