Melanoma Vaccine

Dendritic cell vaccine boosts T cell-mediated immunity to tyrosinase

Published in Cancer Weekly, November 2nd, 2004

Vaccinia virus-transduced, CD34+-derived dendritic cell vaccination boosted T cell-mediated immunity to tyrosinase.

Six American Joint Committee on Cancer stage IV melanoma patients were enrolled into a Phase I study of vaccination with autologous CD34(+)-derived dendritic cells transduced with a modified vaccinia Ankara virus encoding human tyrosinase gene (MVA-hTyr). Patients received a first intravenous injection of 1 x 10⁸ MVA-hTyr-transduced dendritic cells, followed by three s.c. injections at a 14-day interval. Treatment was well tolerated, except for low-grade fever (three of six patients), mild erythema at injection site (five of six), and vitiligo...

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Source: Cancer Weekly (2004-11-02)

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