Cancer Therapy

Protein found to block anticancer drug access, reducing ability to reach tumors

Published in Cancer Weekly, November 9th, 2004

A protein called Mrp4 blocks the access of the anticancer drug topotecan into the brain by transporting this agent back into the bloodstream, thus reducing the ability of this agent to reach tumors.

Results from a series of studies by investigators at St. Jude Children's Research Hospital are published in a recent issue of Molecular and Cellular Biology (MCB).

The St. Jude team, which developed a mouse model lacking the Mrp4 protein, says study results in both mice and tissue cultures suggest that the therapeutic efficacy of drugs targeting central nervous system tumors might be improved by inhibiting this protein, a type of molecule called an...

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Source: Cancer Weekly (2004-11-09)

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