Dermatology
Stat3 is required for the onset of epithelial carcinogenesis
Published in Cancer Weekly, November 9th, 2004
"Constitutive activation of signal transducer and activator of transcription 3 (Stat3) has been found in a wide spectrum of human malignancies. Here, we have assessed the effect of Stat3 deficiency on skin tumor development using the 2-stage chemical carcinogenesis model. The epidermis of Stat3-deficient mice showed a significantly reduced proliferative response following treatment with the tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA) because of a defect in G1-to-S-phase cell cycle progression," scientists in the United States report.
"Treatment with the tumor initiator...
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Source: Cancer Weekly (2004-11-09)
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