Apoptosis
Oxidative stress and caspase activation involved in paclitaxel-induced apoptosis
Published in Cancer Weekly, November 9th, 2004
According to a study from Taiwan, "Paclitaxel has significant antitumor activity in several human tumors, including Kaposi sarcoma (KS). Human herpesvirus 8 (HHV-8) is implicated in all forms of Kaposi sarcoma, primary effusion lymphoma (PEL), and multicentric Castleman disease (MCD), indicating that it is a DNA tumor virus.
"Since it is difficult to culture cell lines derived from KS patients, we used a cell line derived from PEL (BCBL-1) to investigate whether oxidative stress is involved in the cytotoxicity of paclitaxel on the HHV-8-related tumors."
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Source: Cancer Weekly (2004-11-09)
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