Brain Cancer
Angiogenic cytokines have diverse effects on astrocytoma neovascularization
Published in Cancer Weekly, November 16th, 2004
"Angiogenesis, the development of new vessels from a pre-existing vasculature, accompanies the growth and malignant transformation of astrocytic brain tumors. Neovascularization is essential for sustained tumor growth, and with increasing grade, astrocytic tumors undergo an "angiogenic switch" manifested by marked increases in vessel density and changes in vascular morphology," scientists in the United States report.
"In the quiescent state, endogenous antiangiogenic factors, including endostatin, thrombospondin, and soluble vascular endothelial growth factor receptor-1...
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Source: Cancer Weekly (2004-11-16)
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