Brain Cancer

Study blocks mechanism that lets brain tumors sidetrack immune response

Published in Cancer Weekly, November 16th, 2004

Researchers at Cedars-Sinai's Maxine Dunitz Neurosurgical Institute have described an immune-disruptive process driven by an enzyme that is overexpressed in the cells of many types of tumors, including malignant brain tumors called gliomas.

Blocking the enzyme's expression in laboratory tests interrupted the series of cell-level events and led to the development of cells capable of launching an immune response. This finding supports the suggestion that medications attacking the enzyme may boost the immune system's ability to recognize and target gliomas.

Results of the study on cyclooxygenase-2 (COX-2) appeared in the Journal of Immunology....

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Source: Cancer Weekly (2004-11-16)

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