Breast Cancer

Oncostatin M induces S100A9 gene expression in breast tumor cells

Published in Cancer Weekly, November 16th, 2004

The anti-cancer cytokine oncostatin M induces S100A9 gene expression in breast tumor cells.

OM "strongly inhibits the growth of MCF-7 breast cancer cells through the STAT3 signaling pathway," oncologists in California explained.

In their study, C. Li and coauthors at the VA Palo Alto Healthcare System "performed cDNA microarray analyses to identify novel OM-regulated genes in MCF-7 cells that are downstream effectors of the STAT3 signaling cascade."

Test results revealed that "expression of the calcium-binding protein S100A9 is strongly induced by OM in MCF-7 cells and this induction is markedly reduced in MCF-7-dnStat3 cells that...

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Source: Cancer Weekly (2004-11-16)

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