Cancer Weekly
Susan Hasty, Publisher
Table of Contents . . . November 23rd, 2004
Non-Subscriber - Summaries OnlyRelated Areas: Other Issues in Cancer Weekly | Other Publications
Apoptosis - Capillin induces apoptosis in tumor cells
Colorectal Cancer - Obese women face higher risk for colorectal neoplasia than men
Leukemia - Obesity increases older women's risk of acute myelogenous leukemia
Leukemia Therapy - Guidelines to define therapeutic strategies for leukemia described
Women's Health - FDA approves noninvasive procedure to treat uterine fibroids
Acute Myelogenous Leukemia - Phenotypic karyotype markers identified in AML with t(8;21)
Air Quality - Smoke-free workplace laws provide protection impossible to achieve otherwise
Angiology - Paclitaxel induces G1 arrest in arterial smooth muscle cells
Anti-Infective Agents - Sulfamates offer promise as anti-infective/anticancer agents
Apoptosis - HTLV-1 Tax oncogene causes tumorigenesis
Bladder Cancer - Study shows COMBIDEX aids in diagnosis of metastatic lymph nodes
Blood Banking - SC refrigeration is simple option for autotransplants within few days of harvest
Bone Marrow Transplantation - Bone marrow found for woman seeking South Asian donors
Bone Marrow Transplantation - Patients with impaired LV ejection fraction can achieve long-term survival
Bone Marrow Transplantation - Psychosocial/behavioral variables do not effect 1-year survival after BMT
Brain Tumors - The tyrosine kinase inhibitor ZD6474 strikes down glioma growth in xenografts
Breast Cancer - Company ships first dedicated breast MRI system outside the U.S.
Breast Cancer - Disease and therapy can result in thoracic changes
Breast Cancer - Fruits, vegetables may decrease some women's risk of ER-positive cancer
Breast Cancer - Higher serum relaxin levels associated with metastatic disease
Breast Cancer - Meta-analysis finds glutathione S-transferase M1 status a potential risk factor
Breast Cancer - More testing methods OK'd to select patients who may benefit from Herceptin
Breast Cancer - New protein associated with aggressiveness in breast and ovarian cancer
Breast Cancer - New technique detects microcalcifications more reliably
Breast Cancer - Parity-induced mammary epithelial cells promote tumor growth in transgenic mice
Breast Cancer - Study: "Substantial" genetic influence on dysplastic breast glandular tissue
Breast Cancer - U.S. FDA clears diagnostic viewing of digital mammography
Breast Cancer - Wife of Senator Edwards undergoes tests to determine breast cancer treatment
Breast Cancer - Women put bra art on display to promote health
Breast Cancer Therapy - 111In-DTPA-trastuzumab suitable for clinical use
Breast Cancer Therapy - Celecoxib and alpha-TEA shows promise as combination therapy
Business & Finance - Biopharmaceutical company announces third quarter 2004 results
Business & Finance - Pharma company reports improved financial results
Business & Finance - Pharma company reports third quarter 2004 financial results
Business & Finance - Pharmaceutical company reports financial results
Business Update - Curative Health Services opens new Critical Care Systems' branch locations
Business Update - Elekta expands open systems commitment with new sales consulting agreement
Business Update - Four board members named and new center opened by cancer support group
Business Update - Oncology IT solutions provider expands European radiation oncology business
Cancer & Fertility - Lance Armstrong's former wife summons the courage for her own race
Cancer Diagnostics - NIH grant to be used for study of ATN-161 analogs as cancer imaging agents
Cancer Genetics - BRCA1/2 tests available, but ethics, economics restrain use in France
Cancer Immunology - Phage-based microarrays useful for humoral immune analysis
Cancer Immunotherapy - Anti-ErbB2 antibody cuts off tumor growth
Cancer Proteomics - Cancer-altered metabolism linked to cytochrome c oxidase subunit variation
Cancer Research - Cancer-killing activity of gene-based INGN 241 therapy in tumors identified
Cancer Research - Drug used to stabilize vessels, block cancer cells from leaving bloodstream
Cancer Research - Pharma companies move to next phase of collaboration on cancer targets
Cancer Research - Pharma company provides Tarvacin IND update
Cancer Research - Study sheds light on how poxviruses can jump from species to species
Cancer Screening - EUROGIN data documents cost-effectiveness of DNAwithPap Test
Cancer Therapy - Anticancer agents activate antiangiogenic gene therapy
Cancer Therapy - Biomarkers of effective Herceptin therapy identified
Cancer Therapy - Biopharmaceutical, MGI Pharma announce Dacogen MAA accepted for review by EMEA
Cancer Therapy - Boston study shows experimental cancer drugs getting safer
Cancer Therapy - Company initiates phase I clinical trial for XL999
Cancer Therapy - Data: Provenge extends survival in patients with advanced prostate cancer
Cancer Therapy - Engineered stem cells can home in on tumors and deliver drug payload in mice
Cancer Therapy - Fewer risks seen for patients participating in early-phase cancer drug trials
Cancer Therapy - Genomic response of fission yeast to cisplatin determined
Cancer Therapy - Licensing agreement forged to market aniemetic for chemotherapy patients
Cancer Therapy - Patent granted for production and processing of the reovirus
Cancer Therapy - Pharma company announces completion of recruitment for skin tumor trial
Cancer Therapy - QUADRAMET data presented at Prostate Cancer Foundation scientific retreat
Cancer Therapy - Scientists find key to unlock body's own cancer defense
Cancer Therapy - Stem cells ferry concentrated anticancer drug to tumors
Cancer Therapy - Substance may improve cancer immune therapy, vaccines
Cancer Vaccine - Biotech receives patent allowance for nonlethal hemocyanin extraction method
Cancer Vaccine - Control parameters for dendritic cell-T cell interaction determined
Cancer Vaccine - Heat shock protein gp96 elicits anti-tumor CD8 T cell cytotoxicity
Cancer Vaccine - OX40L exhibits anti-tumor therapeutic efficacy in murine tumor model
Carcinogenicity - Assessing carcinogenic risk in human drug development reviewed
Cardiomyopathy - Animal model systems have increased knowledge of myopathic muscle physiology
Cell Biology - Initial sensor for p53 tumor-suppressing pathway identified
Cervical Cancer - Investigational vaccine reduces risk of HPV-related cervical cancer
Cervical Cancer - Irinotecan plus nedaplatin with rhG-CSF shows therapeutic promise
Cervical Cancer - Plasma HPV DNA may be useful to monitor therapy and disease progression
Cervical Cancer - SELDI MS plus proteomics scoring distinguishes cancerous from normal cervix
Cervical Cancer - Study: No justification for colposcopy in screening of young women
Chemotherapy - APE/redox effector factor protein is a target for overcoming drug resistance
Chronic Lymphocytic Leukemia - Utility of antibody-based CLL treatments reviewed
Collaborations - ComGenex, partner, expand their drug-discovery collaboration
Collaborations - Companies announce collaboration for novel TFPI peptides
Collaborations - Companies collaborate on oncology market research
Collaborations - Deal signed with Tulane for potential anticancer agents
Colon Cancer - Brochure helps explain treatments for colorectal cancer
Colon Cancer - Capsule endoscopy aids in detection of small bowel tumors
Colon Cancer - Enhanced aspirin holds promise as colon cancer preventive agent
Colon Cancer - MOK direct target gene for Cdx2; may be involved in intestinal epithelial cells
Colon Cancer - Model suggests higher mortality for virtual colonoscopy
Colon Cancer - Novel Bcl-2 family gene associated with progression of colon cancer
Colon Cancer - Obese women face higher risk of colorectal tumors
Colon Cancer - Smoking increases risk of colon polyps
Colon Cancer - Study reveals genetic link to colon cancer
Colon Cancer - Targeted therapy + efficient chemotherapy increases colorectal cancer survival
Colorectal Cancer - Early screening important for African Americans, Hispanics
Colorectal Cancer - Excessive alcohol intake plus low folate increase risk of colorectal cancer
Colorectal Cancer - Positive opinion granted in Europe for metastatic colorectal cancer therapy
Colorectal Cancer - Screening for variety of genes could determine bowel cancer risk
Complementary & Alternative Medicine - Studies suggest green tea/tea polyphenols lower cancer risk/inhibits tumors
DNA Research - Role of XPC protein in cellular response to cisplatin treatment clarified
Dermatology - Apaf-1 may sensitize human cutaneous melanoma to cancer therapy
Diagnostics - Nanogen introduces diagnostic testing and diagnostic development platform
Down Syndrome - Gene signatures of transient and acute megakaryoblastic leukemia identified
Drug Delivery - Drug-loaded micelles reported cytotoxic in human breast cancer cells
Drug Delivery - Microemulsion systems show promise for transdermal triptolide delivery
Drug Development - Anti-CEA antibody T84.66 humanized
Drug Development - Cancer-focused company reports atomic structure of c-KIT in complex with Gleevec
Drug Development - Novel quinolones have promising antitumor activity
Drug Development - Novel substrate phage display screens for treatment-induced proteomic changes
Drug Development - Screening assay devised for inhibitors of mitotic kinesin Eg5
Drug Development - Selective heparanase inhibitors halt cancer metastasis
Drug Development - TX-1898 is an antiangiogenic hypoxic cell radiosensitizer
Endometrial Cancer - Height, obesity, and activity level associated with cancer risk
Environmental Health - A long wait for Love Canal health study that promises no answers
Environmental Health - West Virginia residents file lawsuit over chemical leak
Epidemiology - The minimum spanning tree model tracks the source of hepatitis C outbreaks
Epigenetics - Genetic double-agents unmasked
Esophageal Cancer - Studies link obesity to increased frequency of heartburn symptoms
Fibrosarcoma - Tumor reoxygenation compared after carbon-ion and X-ray irradiation
Finance - Biopharmaceutical company reports third quarter financial results
Finance - Cancer research company reports improved third quarter results
Finance - Genomics company reports increased Q3 revenues
Finance - Genomics-based pharma reports on Q3, including advances in pipeline
Finance - Pharmaceutical company reports third quarter results
Formaldehyde Exposure - Formaldehyde-induced DNA adducts biomarkers of nasal cell formaldehyde exposure
Gene Analysis - Microarray-based AMASE offers a novel way to scan for gene mutations
Gene Expression - Sterically stabilized immunolipoplex enhances systemic gene delivery
Gene Mutations - Diagnostic lab offers new gene sequencing service for mutation detection
Gene Mutations - Gene mutations alter myocardial performance via changes in Ca2+ sensitivity
Glioblastoma - 2-Methoxyestradiol inhibits proliferation of normal and neoplastic glial cells
Granular Cell Myoblastoma - Genetic profile of granular cell tumors determined
Head and Neck Cancer - Global gene expression profiles determined in HNSCC tumor lines
Head and Neck Cancer - Suicide gene therapy and radiation kill nasopharyngeal carcinoma xenografts
Healthcare Coverage - Board looks for more funding for breast and cervical cancer screenings
Hepatocellular Carcinoma - Interleukin-12 gene transfer and electrosonporation targets liver cancer
Herpesvirus - E2F1/CDK2 promoter activation requires N- and C-terminal regions of KSHV LANA
Herpesvirus - Kaposi sarcoma-associated herpesvirus immediate early gene activity explored
Human Papillomavirus Vaccine - ISCOMATRIX adjuvant is suitable for use in anticancer vaccines
Hypothyroidism - Thyroid cancer precursor lesions studied in Hashimoto thyroiditis patients
Imaging - Lesion evaluation tool receives FDA clearance
Immunizations - Study indicates vaccine protects against cervical cancer
Information Technology - Cancer institute installs research, management software system
Irradiation - Whole body irradiation damages fibroblasts in wounds
Legal Issues - Washington man sentenced for stealing cancer patient's identity
Letter to the Editor - Study links low HDL levels with increased risk of postmenopausal breast cancer
Leukemia - Antiviral therapy for adult T cell leukemia lymphoma is promising
Leukemia - Nippon Shinyaku Co., Ltd. receives approval to market TRISENOX in Japan
Leukemia - Orphan drug designation granted for the treatment of leukemia
Leukemia - Signaling mechanisms underlie human leukemia cell life/death switching
Leukemia - U.S. FDA grants orphan drug designation to acute myelogenous leukemia drug
Liver Cancer - Hepatitis B virus infection agitates enzymes involved in liver cancer invasion
Liver Cancer - RFA safe for treating liver tumors pushing on GI tract
Lung Cancer - Biotechnology company receives grant to create lung cancer therapies
Lung Cancer - Company develops early diagnostic test for lung cancer
Lung Cancer - EGF receptor gene mutations are common in lung cancers from non-smokers
Lung Cancer - cis-Pt(II) complex of 3-aminoflavone induces lung tumor apoptosis and necrosis
Lymphoma - Childhood allergies appear to increase risk of blood cancers
Medical Devices - NYU Cancer Center features new hyperthermia system
Medical Training - New curriculum seeks to standardize training of cancer physicians worldwide
Medicare - Coverage expansion proposed for cancer patients
Mental Heath - Family therapy reduces stress symptoms in adolescent survivors of cancer
Mesangial Cells - Abnormal light chains induce divergent phenotypic transformations
Mutagenesis - Adenomatous polyposis coli gene isoforms curtail cancer cell growth
Neovascularization - Bone marrow-derived cells do not contribute to tumor endothelialization
Neuroblastoma Therapy - Microtubule alterations identified in drug-resistant tumor cells
Neuroscience - Antiangiogenic protein fragments harbor amyloid characteristics
Nicotine Addiction - Cigarette smoking a serious public health threat in China
Nicotine Addiction - Smoking triggers early onset of pancreatic cancer
Non-Hodgkin Lymphoma - Antibodies with activity against non-Hodgkin lymphomas characterized
Non-Hodgkin Lymphoma - BEAM with only cytokine support effective in high-risk patients
Nutrition - Eating fruits, vegetables reduces cardiovascular disease, but not cancer
Nutrition - Study links eating fruit and vegetables with heart health
Oncogenesis - Adenoma to carcinoma hTR expression not linked to promoter methylation
Oncogenesis - Chromosome 12 encodes for genes that suppress pancreatic cancer growth
Oncogenesis - Hepatitis B X protein blocks transcription-coupled nucleotide excision repair
Oncogenesis - Members of the RB/E2F family of proteins cause aberrant survivin expression
Oncology - Bcl-xL gene overexpression boosts breast cancer lymph node metastasis
Oncology - Clinical trials announced for inhaled cancer pain medication
Oncology - Cyclooxygenase-2 expression aligns with transitional cell carcinoma invasion
Oncology - Disulfiram combats melanoma metastasis
Oncology - Genetic counselors and advocacy group develop genetic discrimination brochure
Oncology - KL-6 is a serological marker for liver cancer in patients with hepatitis C
Oncology - Tumors exposed to chronic hypoxia show changes in microvascular function
Oncolysis - Antisense targeting of anti-apoptosis proteins radiosensitizes lung cancer
Ovarian Autotransplantation - Doctors transplant ovary to woman's arm to preserve her fertility
Ovarian Cancer - Inhibitory protein involved in cancer cell apoptosis and cisplatin sensitivity
Ovarian Cancer - Second-line therapy of advanced disease with GnRH analogs shows promise
Pediatric Cancer - Nongenetic causes are most likely risk factors for childhood cancer development
Pediatric Leukemia - Donor characteristics/herpesvirus exposure impact survival in pediatric leukemia
Pediatrics - Specialists' call on European Union to improve childhood cancer treatment
Personnel - BioSciences company adds to scientific advisory board
Personnel - Biopharma company names senior vice president of sales and marketing
Personnel - Guenter Schirmer, MD, named medical director by drug developer
Personnel - John E. Ezcurra named director of manufacturing by oncology-focused company
Personnel - Timothy Adams named CFO of woman's health-focused device company
Personnel - Wade Sexton, MD, joins Genitourinary Oncology Program at Moffitt cancer center
Photoaging - Solar UV irradiation reduces collagen by blocking TGF-betaRII/Smad signaling
Prostate Cancer - Blocking gene opens avenues for treating prostate cancer
Prostate Cancer - CB7630 phase I data presented at Prostate Cancer Foundation scientific retreat
Prostate Cancer - CYP1B1 and PR polymorphisms may be associated with prostate cancer risk
Prostate Cancer - Foundation announces Coffey award recipients for commitment to prostate cancer
Prostate Cancer - Luteinizing-hormone-releasing-hormone causes prostatic atrophy
Prostate Cancer - Postoperative radiotherapy improves progression-free survival
Prostate Cancer - Vitamin D3 -modulated genes identified in prostate tumor cells
Pulmonary Fibrosis - Anticancer drug to fight fatal lung disease
Radiation Therapy - Troxerutin can protect non-malignant tissue from radiation damage
Radiotherapy - GENEPI could be tool to refine and fine-tune treatment for cancer
Radiotherapy - Increased investment in radiology will improve cure rates for cancer patients
Renal Cell Carcinoma - Patient enrollment commences for IMOxine phase II trial in renal cell carcinoma
Renal Cell Carcinoma - U.S. FDA grants orphan drug designation to BAY 43-9006
Renal Disease - U.S. FDA approves phosphate binder for patients with end-stage renal disease
Sarcoma - Brachytherapy holds promise as treatment for once-debilitating cancers
Skin Cancer - New study examines skin protection in children
Skin Cancer - Researchers discover potential skin cancer prevention target
Small Cell Lung Cancer - Cancer therapeutics development company files IND for small cell lung cancer
Smoking Cessation - Funding granted to study doctors' smoking cessation practices
Stem Cell Transplant-Related Aspergillosis - Aspergillosis occurs later after reduced intensity versus regular SCT
Stem Cell Transplantation - Multiagent strategy lowers regimen-related toxicity in children undergoing HSCT
Stem Cells - Cancer center doctor receives $25,000 award for research
Stomach Cancer - Hot-water extracts from adzuki beans reported to suppress tumorigenesis
Tobacco Use - Smoking among University of Minnesota students declines
Tumor Suppression - Mutant p53 influences hypoxia-induced gene expression in tumor cells
Ulcerative Colitis - Pathway independent of p53 appears to exist related to ulcerative colitis
Urological Oncology - Downregulated Ets2 transcription factor halts prostate cancer cell growth
Urology - Vascular endothelial growth factor shares in prostate blood flow regulation
Uterine Fibroids - FDA approves ExAblate 2000 system as noninvasive surgery for uterine fibroids
Vaccine Development - License agreement reached for MedPulser DNA Delivery System in two applications
Ventricular Morphology - Na+/K+-ATPase alpha1B1 is required for cardiomyocyte morphology
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