Cancer Weekly

Cancer Genetics - Largest study on BRCA1/2 gene testing criteria clarifies other cancer links

Cancer Vaccine - Antibodies redirect cytolytic capacity of cytotoxic T lymphocytes

Cervical Cancer - Telomere attrition occurs mostly in precursor lesions in early carcinogenesis

Oncology - Neurotransmitters can induce metastatic tumor cell migration

Proteomics - Pharmacoproteomic approach to drug activity reviewed

AL Amyloidosis - High-dose melphalan and ASCT improves quality of life of AL amyloidosis patients

Acute Lymphoblastic Leukemia - Advances in ALL treatment may lead to elimination of irradiation

Acute Myelogenous Leukemia - AML samples with FLT3/ITD mutations preferentially killed by FLT3 inhibition

Acute Myeloid Leukemia - Idarubicin and busulfan feasible for elderly AML patients undergoing ASCT

Antisense Technology - Suppressed E1AF limits the invasiveness of cervical cancer

Apoptosis - M4N induces growth arrest/apoptosis by inhibiting Cdc2 and survivin expression

Aspergillosis - Aspergillosis: Emerging infection in critically ill patients without malignancy

Basal Cell Carcinoma - Basal cell carcinoma rates continuously increasing in the Netherlands since 1973

Benign Prostatic Hyperplasia - Newly discovered genetic biomarkers separates BPH from prostate cancer

Biotechnology - MTT/ATP/calcein assays similarly predict potency of cytotoxic anticancer agents

Bone Marrow Failure - Murine model developed for bone marrow failure

Bone Marrow Transplantation - Suicide gene constructs may be effective graft-versus-leukemia therapy

Brain Cancer - New gene target found for common brain tumors in children

Brain Tumor - FDA grants priority review status for brain tumor drug; EMEA application made

Breast Cancer - 'Songs for Life' CD created to mark Breast Cancer Awareness Month

Breast Cancer - Antiestrogenic DTACs inhibit estrogen receptor alpha-mediated transcription

Breast Cancer - Breast size doesn't appear to be contributing factor in cancer risk

Breast Cancer - Chromosome 17 genes with abnormal expression identified

Breast Cancer - Death receptor 4 kills breast cancer cells despite the absence of TRAIL

Breast Cancer - Femara gets U.S. FDA nod as post-tamoxifen treatment for early breast cancer

Breast Cancer - Gestational hormones may play etiologic role in breast cancer

Breast Cancer - Intra-operative specimen radiographs help minimize necessary tissue excision

Breast Cancer - Investigators awarded grants from U.S. DoD Breast Cancer Research Program

Breast Cancer - New breast exam recommendations issued

Breast Cancer - Older unmarried women distant from screening centers forgo mammography

Breast Cancer - Patients sought for study of online, face-to-face breast cancer support groups

Breast Cancer - Pilot study examines new radiofrequency ablation-assisted lumpectomy

Breast Cancer - Serum sex hormones associated with increased cancer risk in younger women

Breast Cancer - Significantly more poorly differentiated tumors found in younger women

Breast Cancer - Smoking linked to postmenopausal disease in women with high estrogen levels

Breast Cancer - Study assesses early cancer deaths in women aged 40-74 years in north Sweden

Breast Cancer - Survival benefit confirmed in patients with brain metastases from breast cancer

Breast Cancer - Tc-99m-MIBI scintimammography inappropriate for routine evaluation of lesions

Breast Cancer - Total number of cancer cells reflects prognosis

Breast Cancer Prevention - South Carolina breast cancer program should be expanded to include more women

Breast Cancer Risk - Women wrongly told abortion could increase breast cancer risk

Burkitt Lymphoma - Intensive/short-term Burkitt lymphoma chemotherapy effective/manageable toxicity

Business & Finance - Biopharma company presents data on NeoLipid compound, releases financial results

Business & Finance - Cancer therapeutics development company reports financial results

Business & Finance - Drug discovery company announces third quarter 2004 results

Business & Finance - Medical oncology device company announces third quarter, 9-month results

Business & Finance - Pharma company reports third quarter 2004 results

Business Update - Diagnostic company discontinues orthopedic division to focus on cancer products

Business Update - Pharma company purchases California discovery and development campus

Cancer Genetics - Centrosome-associated PIBF gene is overexpressed in highly proliferating cells

Cancer Immunotherapy - Immune receptors for Ganoderma lucidum polysaccharides identified

Cancer Prognosis - Molecular elements define lung adenocarcinoma and bronchioloalveolar cancer

Cancer Research - Negative outcome on malignant melanoma trial reported

Cancer Research - Pharma company announces licensing of anticancer compounds

Cancer Research - Pharma company offers data on Yondelis and Aplidin at conference

Cancer Risk Factor - Childhood obesity increases later cancer risk, especially for smokers

Cancer Risk Factor - DNA damage and repair in type 2 diabetes reviewed

Cancer Therapy - Beta-lactams hold promise as anticancer chemotherapeutic drugs

Cancer Therapy - Biotech company announces issuance of reovirus patent

Cancer Therapy - Cleveland Clinic installs BioScanIR System to monitor cancer therapy response

Cancer Therapy - Company achieves commercial scale of antigen for Provenge

Cancer Therapy - Company initiates phase I trial with cancer drug candidate GX15-070

Cancer Therapy - New data presented gefitinib's antitomor activity

Cancer Therapy - Pharma company presents data on Xcytrin Injection trial

Cancer Therapy - Plasminogen activator and captopril combine to eliminate melanoma growth

Cancer Therapy - U.S. FDA fast-tracks phenoxodiol for recurrent ovarian cancer

Cancer Thereapy - NeoRecormon may reduce risk of tumor progression in patients with anemia

Cancer Vaccine - Cancer vaccines must break immune tolerance to malignant cells

Cancer Vaccine - IL-6 regulates dendritic cell differentiation through STAT3 activation

Cancer Vaccine - Lipid-core-peptides increase adjuvant activity of T cell peptides

Cancer Vaccine - Melanoma vaccination results presented at conference

Cancer Vaccine - PHB1/PHB2 identified as blood-borne tumor antigens

Cancer Vaccine - Susceptibility of tumors to immunotherapy changes during maturation

Carcinogenesis - Allelic loss on chromosome 4q is linked to hepatitis B-related liver cancer

Cardiac Biomarker - Cardiac troponins/NT-proBNP prognostic of amyloidosis PBSCT survival

Cell Biology - Researchers discover transport molecule that allows boron into cells

Cervical Cancer - Gene expression profiles can differentiate cervical precancers

Cervical Cancer - HPV vaccine shown to "substantially" reduce cervical cancer

Cervical Cancer - Low-resource settings need sensitive, less expensive and sophisticated HPV test

Cervical Cancer - Screening among South Asian women in U.K. city has increased, study finds

Cervical Cancer - Two pathways can activate IL-2 receptor signaling in HPV-associated cancer

Cigarette Smoke - Low levels of cigarette smoke induce irreversible change in cell chromosomes

Clinical Trials - NDA for anticancer therapeutic drug submitted to U.S. FDA by two drug companies

Clinical Update - Company details clinical development plan for CG53135 and CR002

Collaborations - Cancer research deal signed for development of VEGF-B

Collaborations - Collaboration on novel cancer targets extended

Collaborations - Grant Ventures announces collaboration with Cleveland Clinic subsidiary

Colon Cancer - Anti-proliferative mechanisms of zinc in colon tumor cells clarified

Colon Cancer - Colon cancer trial information presented at conference

Colon Cancer - Drug-induced polyploidization of metastatic colon tumor cells described

Colon Cancer - Oral targeted colon cancer drug shown to improve outcomes, cut post-op costs

Colon Cancer - Progressive stages of 5-fluorouracil resistance characterized

Colon Cancer - Role of cancer-associated stromal fibroblasts in liver metastasis determined

Colon Cancer - Trials highlight Erbitux potential in first-line treatment of colorectal cancer

Colon Cancer - U.S. FDA clears second stage of CoFactor phase II trial

Colorectal Cancer - Caffeinated coffee, but not decaf or tea, may have some protective effect

Colorectal Cancer - Panitumumab with chemotherapy shows promise as colorectal cancer treatment

Colorectal Cancer - Serum bilirubin levels may have chemoprotective function

Colorectal Cancer - Tumor vessel surfaces reflect survival trends in rectal cancer patients

Crohn Disease - REMICADE safety data presented for Crohn disease therapy

Cytomegalovirus Infection - Oral valganciclovir equivalent to oral ganciclovir for CMV prevention

Diabetes - Research institute announces discovery on the virus' role in autoimmune disease

Disease Associations - Environmental tobacco smoke not associated with breast cancer incidence

Disease Associations - Higher risk of cervical cancer, lower endometrial cancer risk in moms of twins

Disease Associations - Link between HRT and hormone-dependent cancers studied in Norwegian women

Disease Associations - Patients with hepatitis C virus-associated lymphomas respond to common therapy

Disease Prevention - Phytoestrogens inhibit mRNA expression, aromatase activity human GL cells

Drug Delivery - Researchers report on pulsatile dosing of antimicrobials at conference

Drug Delivery - Transferrin-conjugated paclitaxel-loaded nanoparticles attack prostate cancer

Drug Development - Chemotherapy targeted to cancers through tumoral hormone receptors

Drug Discovery - Biotech company announces second license agreement with AstraZeneca

Endocrinology - Estrogen regulates GILZ gene in cell-specific manner

Endocrinology - Transforming growth factor regulates angiogenic factors in pituitary cells

Endometrial Cancer - Genetic markers of type I and II endometrial carcinoma identified

Endometrial Cancer - HNF1alpha inactivation or haploinsufficiency may contribute to carcinogenesis

Endometrial Cancer - PGF-FP receptor signaling may regulate endometrial vascular function

Endoscopy - PillCam reported as accurate as EGD in visualizing esophagus abnormalities

Epidemiology - Cervical cancer incidence, although declining, is still high in Curacao

Erythropoietin - Transgenic EPO expression overcomes lethality caused by c-Kit(w/w) mutation