Receptor Studies
Radiolabeling affects the biodistribution of angiogenesis-targeting ligands
Published in Cancer Weekly, November 30th, 2004
According to recent research from the United States, "the formation of new blood vessels (angiogenesis) is a feature common to all solid tumors. The integrin receptor alpha(v)beta(3), which is found on endothelial cells lining newly growing blood vessels at a higher density than on mature blood vessels, is being explored as a marker for tumor angiogenesis. Bitistatin, a member of the disintegrin family of polypeptides, has affinity for alpha(v)beta(3) integrins."
"To determine whether radiolabeled bitistatin could target tumors, its biodistribution was tested in...
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Source: Cancer Weekly (2004-11-30)
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