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Acute Lymphoblastic Leukemia

Advances in ALL treatment may lead to elimination of irradiation

Published in Cancer Weekly, November 30th, 2004

Improved risk classification for patients with acute lymphoblastic leukemia (ALL), coupled with more intensive intrathecal chemotherapy for high risk patients and the use of a drug called dexamethasone, could one day permit physicians to omit irradiation as a part of routine treatment.

These findings emerged from a clinical trial conducted by investigators at St. Jude Children's Research Hospital. For intrathecal chemotherapy the drugs are injected into the cerebrospinal fluid-filled spaces between the thin membranes covering the spinal cord.

The researchers base their conclusion on results of a study of ALL treatment at St. Jude called Total Therapy...

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