Cancer Weekly
Susan Hasty, Publisher
Table of Contents . . . December 7th, 2004
Non-Subscriber - Summaries OnlyRelated Areas: Other Issues in Cancer Weekly | Other Publications
Breast Cancer - Topoisomerase II alpha is a prognostic indicator in breast cancer
Cervical Cancer - Study: Shorter, more aggressive treatments better control disease
Colon Cancer - Genetic markers of tumorogenic aberrant crypt foci identified
Renal Cancer - Dendritic cell-tumor fusion vaccines being developed for renal cell carcinoma
Renal-Cell Cancer - Allogeneic stem-cell transplantation for renal-cell cancer reviewed
Abortion - Corrections being made to Louisiana abortion brochure
Acute Lymphoblastic Leukemia - Oral etoposide has a cytoreductive effect in relapsed ALL
Acute Myeloid Leukemia - L-ascorbic acid represses NF-kappa B/COX-2 expression in acute myeloid leukemia
Adenovirus - Nuclear localization of adenovirus E4orf4 protein correlates with cell death
Aging - Scientists successful in "death clock" gene hunt
Alcoholic Liver Disease - Intracellular SAH removal may be therapeutic option in alcoholic liver disease
Anemia - Study: FG-2216 increases endogenous EPO production in humans
Antisense Technology - GAD 67KD antisense leaves colon cancer cells susceptible to cancer therapy
Antitumor Activity - Intratumoral CCL5 overexpression delays tumor growth
Apoptosis - NF-kappa B activation by API2/MALT1 fusions inhibits p53 dependant apoptosis
Autoimmune Hemolytic Anemia - High incidence of autoimmune hemolytic anemia complicating SCT in children
Awards - Cancer reference laboratory named to Deloitte's Fast 500 list
Awards - Scott Hawley named American Cancer Society research professor, awarded $300,000
Biological Therapies - Plasma elements deem VEGF a biomarker for intestinal cancer transformation
Biological Therapy - Type-1 innate and acquired immunity play crucial roles in tumor immunotherapy
Bladder Cancer - Promising data presented on phase 2 trial drug for superficial bladder cancer
Bone Marrow Transplantation - Novel technique isolates/tracks rare lymphoid stem cell that facilitates BMT
Bone Neoplasms - Trisacryl gelatin microspheres effective for preoperative embolization
Brain Cancer - Post-therapy damage in medulloblastoma patients can be mistaken for new tumors
Breast Cancer - "Knowledge management" system could "revolutionize" treatment
Breast Cancer - GATA3 mutations identified in breast tumors
Breast Cancer - Accelerated partial breast irradiation new option for breast cancer patients
Breast Cancer - Apoptotic response of tamoxifen-resistant breast tumor cells clarified
Breast Cancer - Breast cancer study examines new radiofrequency ablation assisted lumpectomy
Breast Cancer - Chemotherapies have varied effects on menopausal symptoms of cancer patients
Breast Cancer - Data on radiation dose from digital mammography reported from large study
Breast Cancer - Elizabeth Edwards's diagnosis encourages others to get check-ups
Breast Cancer - Endogenous BRCA1-IRIS may influence DNA replication initiation machinery
Breast Cancer - Enhancing cancerous area on MR mammography compared with pathological exam
Breast Cancer - Genes linked to breast tumor progression and/or metastasis identified
Breast Cancer - HER2-positive disease invades organs due to fatal chemical attraction
Breast Cancer - Hierarchical clustering of breast tumor immunomarkers has high prognostic value
Breast Cancer - In BRCA1/2 mutation carriers, cancer may mimic benign lesions on mammogram
Breast Cancer - New surgical technique determines if cancer has spread
Breast Cancer - Obesity, lymph node status, and prognosis in breast cancer explored
Breast Cancer - Patients receiving taxane-based chemotherapy not at higher risk of pneumonitis
Breast Cancer - Phage display library from lymph nodes of breast cancer patients constructed
Breast Cancer - Plasma prolactin levels associated with increased postmenopausal disease risk
Breast Cancer - Private practice in Munich, Germany, selects mammography system
Breast Cancer - Saudi Arabia: National guidelines on breast cancer management needed
Breast Cancer - Trial evaluates supplemental screening sonography in dense breasts
Breast Cancer - Women willing to deal with negative aspects of screening to gain benefit
Business & Finance - Biopharma reports third quarter 2004 results, clinical achievements
Business & Finance - Biopharmaceuticals company announces third quarter results, progress made
Business & Finance - Biotech company announces restructured agreement for cancer drug
Business & Finance - Dermatology pharmaceutical company announces financing, new hires
Business & Finance - Developer of surgical and diagnostic products announces financial results
Business & Finance - Pharmaceutical firm reports loss of $0.18 per share
Business Update - Biotech establishes new business units for pain and oncology
Business Update - ComfortScan agreements inked in Canada, Italy, and Russia
Business Update - IUN and Theragenics Corporation sign 3-year strategic alliance agreement
Business Update - Molecular diagnostics company announces expansion of diagnostic pipeline
Business Update - New company to develop, produce patient-specific cancer vaccines
Cancer Genetics - BRCA1 missense variant thwarts transcriptional activity
Cancer Genetics - Clinical studies needed to evaluate role of BRCA1 in chemotherapy response
Cancer Genetics - SOCS1 and 2 genes suppress growth of ovarian and breast carcinoma cells
Cancer Immunoprevention - Fused cell vaccination and CpG oligodeoxynucleotides reject tumor recurrence
Cancer Management - Standardized reviews of glioblastoma vascular patterns assist treatment choice
Cancer Research - Vascular targeting agent, radiation reduces tumor growth by 98% in animals study
Cancer Risk Factor - Hepatitis C infection encourages liver cancer recurrence after resection
Cancer Screening - OC Auto Micro 80 analyzer detects blood in stool samples
Cancer Screening - Program to implement required Pap interpretation proficiency testing announced
Cancer Suppression - p21Waf1 gene transfer via gene gun technology limits esophageal cancer growth
Cancer Therapy - European cancer organization offers guidelines for treating anemia
Cancer Therapy - Radiation therapy systems selected to supply Wave 7 of UK Cancer Plan
Cancer Therapy - Skin cancer study using MedPulser Electroporation Therapy system begins
Cancer Therapy - VELCADE gets fast track status for relapsed and refractory mantle cell lymphoma
Cancer Vaccine - Listeria-based cancer vaccines segregate immunogenicity from toxicity
Cancer Vaccine - Dendritic cells boost antitumor activity of adoptively transferred T cells
Cancer Vaccine - Expression of the cell surface mucin gene family in adenocarcinomas reported
Cancer Vaccine - IL-13 antagonist and Pseudomonas toxin fusion protein is anticancer
Cancer Vaccine - Tumor vaccine therapy reviewed
Cancer Vaccines - Interleukin-15 transfection plus CD8+ T cells cause colon cancer rejection
Cell Biology - Biopharma company's cell cycle inhibitor work published in Science
Cell Biology - New evidence found for cancer stem cells
Cervical Cancer - Chemoradiation with gemcitabine an alternative for patients with renal failure
Cervical Cancer - Clinical trial investigates food supplement's preventive effects
Cervical Cancer - HPV 16 infection a risk factor for disease progression in younger women
Cervical Cancer - Small cell neuroendocrine carcinomas of the uterine cervix characterized
Cervical Cancer - Study says Ireland's high death rate is due to lack of screening program
Chemoresistance - Interleukin-1 beta-mediated blast survival may contribute to chemoresistance
Chemotherapy - IMPAC announces support for CMS quality of care assessment in chemotherapy
Chronic Lymphocytic Leukemia - Primary endpoint achieved in phase 3 trial of genasense plus chemotherapy
Chronic Obstructive Pulmonary Disease - Smoking cessation can improve survival among severe COPD patients, study shows
Collaborations - Affitech, Peregrine expand collaboration to develop new fully human antibodies
Collaborations - Anti-cancer vaccine R&D agreement signed
Collaborations - Biopharma, consortium collaborate to treat brain cancer patients
Collaborations - Companies combine technologies to search for cancer-fighting compounds
Collaborations - Companies introduce solid support product for manufacture of oligonucleotides
Colon Cancer - ELOXATIN approved for colon cancer treatment following surgery
Complementary and Alternative Medicine - Agaricus blazei extract halts cancer and metastasis in tumor models
Coronary Artery Disease - Data on coronary artery disease presented at AHA sessions
Crohn Disease - Lipoxin may provide a promising new oral treatment for Crohn disease
DNA Vaccine - DNA vaccines induce epitope-specific CTLs against histocompatibility antigens
Dermatology - T-oligos trigger anticancer activity in melanoma cells
Diagnostics - Indian pharmaceutical company launches new cancer diagnostic product
Diagnostics - Multiplex RT-PCR assay detects balanced translocations in leukemia patients
Drug Delivery - Kinetics of paclitaxel release from blended-polymer microspheres evaluated
Drug Development - Cervical cancer's image as a niche market hinders drug development
Drug Development - Elderly cancer patients significantly underrepresented in cancer trials
Drug Development - Native American project: increasing access to clinical trials
Drug Development - Novartis picks drug for development from protein kinase research collaboration
Drug Development - U.S. company to test use of obesity/smoking pill for heart disease
Embryogenesis - GRIM-19 is essential for assembly and function of mitochondrial complex I
Endocrinology - Estrogen uses PAF-mediated NF-kappaB to stimulate angiogenesis
Endometriosis - Recent advances in endometriosis highlighted
Environmental Health - U.S. Army developing plan to burn buildings with toxins
Enzymology - Cyclooxygenase-2 supports angiogenic growth in malignant fibrous histiocytomas
Enzymology - PinX1 may regulate telomere length in human hepatocellular carcinoma
Finance - Biopharmaceutical company reports third quarter 2004 results
Finance - GLIADEL Wafer maker reports Q3 net loss of $14.5 million
Finance - Grants awarded for antibody research related to angiogenesis
Finance - INTERCEPT maker reports Q3 revenue of $3.5 million
Finance - MyVax maker announces Q3 net loss of $6.7 million
Finance - Offer made to skin care company shareholders to raise funds for clinical trials
Finance - Oncology company announces effectiveness of S-3 Registration Statement
Finance - Oncology-focused biopharmacology company reports third quarter financials
Finance - Pharmaceutical company reports third quarter revenue increase of 58%
Finance - QUADRAMET maker reports increased revenues
Finance - Vaccine maker reports Q3 revenues of $69,000
Gastric Cancer - IM and gastric adenocarcinoma may share the same genetic alterations
Gastric Cancer - Novel genes linked to 5-FU resistance identified in gastric tumor cells
Gastroenterology - Cytotoxic gene therapy is selective for human pancreatic cancer cells
Gastroenterology - Specificity proteins are linked to the angiogenesis of pancreatic cancer
Gene Delivery - Steroids and cholesterol enhance liposomal transfection of breast cancer cells
Gene Silencing - Silenced heat shock protein 27 discourages prostate cancer progression
Genetics & Genomics - Collaborative thrombophilia-markers study complete
Genomics Research - Virginia Tech, research institute sign memorandum to conduct genomics research
Glioma - Selective targeting of VR1 by AEA: A promising area for research
Gynecology - Hyaluronan synthase 1 expression associates with ovarian cancer progression
Gynecology - Sindbis viral vectors detect and suppress advanced ovarian cancer xenografts
Head and Neck Cancer - Advexin with chemotherapy promotes head and neck cancer cell death in studies
Healthcare Fraud - Urologist pleads guilty to healthcare fraud
Hepatic Cancer - Phase I data evaluating BAY 43-9006 plus conventional chemo released
Hepatocellular Carcinoma - Improved dose calculation method devised for yttrium-90 microspheres
Human Papillomavirus - Inflammatory responses in cervical neoplasia suppressed in HIV-positive women
Human Papillomavirus - Methods of identifying new antigenic epitopes of HPV 16 developed
Human Papillomavirus - Prevalence of HPV infection differs for men and women
Human Papillomavirus Vaccine - Dendritic cell-based vaccines effective against HPV-associated tumors
Imaging Technology - Digital slot-scan mammography may reduce X-ray dose, improve image quality
Immunology - Heat shock protein suicide gene-based tumor vaccine provokes antitumor activity
Immunotherapy - Dendritic-like cells derived from t(9;22) ALL blasts may be useful immunotherapy
Information Technology - Drug Web sites foster doctor and patient loyalty
Kaposi Sarcoma-Associated Herpesvirus - Herpesvirus saimiri ORF73 modulates tumor suppressor proteins p53 and pRb
Kaposi Sarcoma-Associated Herpesvirus - KSHV LANA up-regulates hTERT promoter transcription through Sp1 interaction
Kidney Disease - Company reports beneficial effects of seliciclib in models of kidney disease
Legal Issues - Ablation and vacuum-technology company resolves class-action litigation
Leukemia Vaccine - Leukemic cells have high B7-H1 and B7.1 expression and resist lysis
Liver Disease - Company presents new immunomodulatory research at liver disease conference
Liver Transplantation - Sirolimus is suited for patients given liver transplants due to liver cancer
Lung Cancer - Cancer vaccine helped patients in phase IIb trial survive 4.4 months longer
Lung Cancer - Genes overexpressed in NSCLC identified
Lung Cancer - New protein identified in development of lung cancer
Lymphoma - NCI scientists create model that predicts follicular lymphoma survival
Lymphoma - Prostatic acid phosphatase is marker for intravascular large B-cell lymphoma
Malignancies - HGS-TR2J, TRAIL-R2 preclinical study results presented at 29th Congress of ESMO
Mammography - Poland's leading cancer institute selects CT laser mammography system
Market Analysis - Report details progress in the leukemia therapeutics market
Medical Education - South Florida cancer center seeks students for summer intern program
Melanoma - Data updates from phase 2 trial for metastatic melanoma drug presented
Melanoma Vaccine - Quiescent phenotype of tumor-specific CD8+ T cells following immunization
Metastatic Lung Cancer - Positive results reported from INGN 401 studies in metastatic lung cancer
Multiple Myeloma - Anti-alpha4 integrin antibody inhibits tumor cell growth and osteolysis
Natural Products - Anticancer effects are increased with increased levels of alliin in garlic
Nitrite Inhalant - Macrophage IL-1 beta production inhibits caspase-1 after nitrite inhalation
Non-Hodgkin Lymphoma - Marqibo NDS filed with TPD of Health Canada for non-Hodgkin lymphoma
Non-Hodgkin Lymphoma - Yttrium 90-labeled ibritumomab effective for NHL patients
Nutrition - Cancer experts comment on new diet-cancer study
Oncogenesis - Aged mice develop protective antitumor immune responses with costimulation
Oncogenesis - Hepatitis C virus infection elevates one's risk for non-Hodgkin lymphoma
Oncogenesis - Nuclear factor-kappa B rules the malignant phenotype of squamous cell carcinoma
Oncology - $10 million grant to evaluate lifestyle changes on breast cancer patients
Oncology - Angiopoietin-2 is a prognostic marker for non-small cell lung cancer
Oncology - Bcl-xL knockdown strengthens TRAIL-induced death in prostate cancer cells
Oncology - Bevacizumab reduces tumor progression in patients with metastatic renal cancer
Oncology - Combined chemotherapy and immunotherapy generates tumor rejection
Oncology - Ets-1 transcription factors are involved in human breast cancer metastasis
Oncology - Occult neoplastic cells predict recurrence in node-negative breast cancer
Oncology - Pharmaceutical company announces Phase I clinical trial for myeloma treatment
Oncology - Plasma from pregnant rats has antitumoral activity
Oncology - STAG1 is a chief intermediary of the p53-dependent pro-apoptotic pathway
Oncology - The Shc protein is involved in a continuum leading to liver cancer
Oncology - Tumor MGC4175 expression linked to taxol and doxorubicin resistance
Oncology - Xcytrin data prsented at Chemotherapy Foundation Symposium XXII
Oncology Research - Survivor, patient advocacy group started to support cancer advancements
Oral Health - The market for betel quid is increasing despite risk to oral health
Osteosarcoma - Cytogenetic profile of tumor cells clarified
Ovarian Cancer - 42-bp deletion within ERCC1 5' UTR can affect therapeutic cisplatin response
Ovarian Cancer - Focal adhesion kinase may be important therapeutic target
Ovarian Cancer - Gene expression profiling aids in ovarian cancer prognosis
Ovarian Cancer - Hypermethylation is a common, relatively early event in ovarian tumorigenesis
Ovarian Cancer - Loss of beta-catenin associated with poor survival
Ovarian Cancer - Study: Urinary incontinence, abdominal pain are key early warning signs
Ovarian Cancer - Trial compares docetaxel to paclitaxel for first-line treatment of cancer
Ovarian Cancer - p53 deficiency alone doesn't prompt ovarian epithelial tumorigenesis in mice
Ovarian cancer - SFRP1 gene is inactivated by promoter methylation in human ovarian cancers
Pancreatic Cancer - Photothermal assay detects nicotine-induced tumor cell apoptosis
Patents - Anticancer drug receives Candian patent
Patient Confidentiality - Woman sues over display of medical file in breast cancer awareness
Pediatric Cancer - U.S. NCI pediatric program established under contract to research hospital
Pediatric Oncology - Gene therapy promoters should be inspected for their effects in local tissues
Personnel - Craig A. Dionne named foundation's executive VP of research and therapeutics
Personnel - James Caggiano named VP sales and marketing; will focus on Provenge
Personnel - Life sciences firm expands board of directors
Personnel - Oncology-focused company names Dr. Gloria Lee VP of clinical R&D
Personnel - Oncology-focused pharmaceutical names new heads of biologics, regulatory affairs
Personnel - Proteomics company appoints new member to scientific advisory board
Preventive Medicine - Despite setbacks, strong growth seen in $7 billion vaccine market
Programmed Cell Death - Autocrine secreted Fas ligand promotes tumor escape mechanisms
Prostate Cancer - CD40 expression in prostate cancer is a potential diagnostic, therapeutic molecule
Prostate Cancer - HRT patches prevent the side effect of osteoporosis during cancer treatment
Prostate Cancer - Ultrasound therapy to treat prostate cancer announced by British company
Receptor Studies - Peripheral benzodiazepine receptor deregulation increases tumorigenicity
Renal Cancer - Utility of radiofrequency ablation reviewed
Renal Tumors - Wake Forest University completes ablate and resect study of renal tumors
Rituximab - Novel assay identifies compounds that enhance rituximab anti-lymphoma activity
Salmonella Vaccine - Delta yej Salmonella mutants induce superior CD8+ T-cell responses
Secondhand Smoke - Dispute over secondhand smoke crucial in $280 billion trial
Skin Cancer - Learning to cover up reduces risk of skin cancer
Skin Cancer - Oxidative stress may play key role in arsenic carcinogenesis
Skin Cancer Marker - HLA A11 is marker for nonmelanomatous skin cancer risk after renal transplant
Smoking Ban - Groups plan 2006 anti-smoking initiative
Smoking Ban - Limited smoking ban gains support in Nevada
Smoking Ban - Portugal prepares to impose ban on smoking in public places
Squamous Cell Cancer - TP53 mutations detected in squamous-cell carcinomas of conjunctiva
Stem Cell Transplantation - Impaired neuromotor function after cancer treatment can improve, study shows
Survival and Mortality - Glioma gene expression profiles predict patient survival
Thyroid Cancer - CD82 may serve as a prognostic marker of metastasis in thyroid cancer
Thyroid Cancer - Combination treatment helps thyroid cancer patients live longer
Tobacco Use - Federal report shows number of Iowa smokers drops
Tobacco Use - Oregon groups seek to reinstate cigarette tax
Transplant Medicine - Salvage liver transplants aid patients without proven residual liver cancer
Tumor Suppression - GST-MDA-7 fusion protein selects for and destroys cancer cells
Tumor Suppression - Monoclonal antibody targeting kininogen domain 5 halts tumor angiogenesis
Urological Oncology - Bladder tumors respond to non-viral tumor necrosis factor-alpha gene transfer
Urology - Survivin down-regulation blocks the growth of bladder cancer cells
Vaccine Development - HER-2 Protein AutoVac starts phase II trial in breast cancer
Vaccine Development - Vaccinia vector with antigen-linked calreticulin elicits an antitumor response
Vector Development - Anionic dendrimers convey antisense oligonucleotides to cancer cell targets
Vector Development - Porcine adenoviral vectors are effective vehicles for gene delivery
Virology - Kaposi sarcoma-associated herpesvirus drives endothelial cell differentiation
Wilms' Tumor Gene Vaccine - Wilms' tumor gene peptide vaccine causes cancer regression
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