Gastric Cancer

Novel genes linked to 5-FU resistance identified in gastric tumor cells

Published in Cancer Weekly, December 7th, 2004

A number of gastric tumor genes have been linked to 5-fluorouracil (5-FU) resistance.

In a recent study from South Korea, conducted to "identify novel genes associated with 5-FU in gastric cancer," the "time-dependent expression profiling of genes in response to 5-FU was examined in 5-FU-sensitive and/or -resistant gastric cancer cell lines using a 'KUGI 14 K cDNA chip' containing 14,081 unigenes obtained from human gastric cancer cell lines and tissues."

"By this analysis, we obtained 13 genes which are directly associated with sensitivity or resistance to 5-FU," reported J.S. Park and coauthors at the Korea Research Institute of Bioscience and...

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Source: Cancer Weekly (2004-12-07)

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