Published in Cancer Weekly, December 7th, 2004
According to A.K. Sood and colleagues, "Focal adhesion kinase (FAK) is a nonreceptor tyrosine kinase that is activated by integrin clustering. There are limited data regarding the functional role of FAK in ovarian cancer migration and invasion. In the current study, FAK expression was evaluated in ovarian cell lines (nontransformed and cancer), 12 benign ovarian samples, and in 79 invasive epithelial ovarian cancers."
FAK was overexpressed in all three ovarian cancer cell lines compared to nontransformed cells.
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