Breast Cancer

Topoisomerase II alpha is a prognostic indicator in breast cancer

Published in Cancer Weekly, December 7th, 2004

Topoisomerase II alpha is a prognostic indicator in breast cancer, pathologists at Tel Aviv University report.

"Topoisomerase II-alpha (Topo II-alpha) is a nuclear enzyme. Its expression rises rapidly at the end of the S to G2/M phase and falls after the mitotic process ends. We have studied the immunohistochemical expression of Topo II-alpha in breast cancer and its correlation with the menopausal state, tumor type, size, lymph node metastases, stage, and estrogen and progesterone positivity," wrote R. Koren and colleagues.

"Histological sections from 50 breast cancers were immunohistochemically stained for Topo II-alpha. The percent of positive...

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Source: Cancer Weekly (2004-12-07)

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