Breast Cancer
Endogenous BRCA1-IRIS may influence DNA replication initiation machinery
Published in Cancer Weekly, December 7th, 2004
According to published research from the United States, "Breast cancer is the most common malignancy among women, and mutations in the BRCA genes produce increased susceptibility to these malignancies in certain families. Here we identify BRCA1-IRIS as a 1399-amino-acid BRCA1 gene product encoded by an uninterrupted open reading frame that extends from codon 1 of the known BRCA1 open reading frame to a termination point 34 triplets into intron 11. Unlike full-length BRCA1 (p220), BRCA1-IRIS is exclusively chromatin-associated, fails to interact with BARD1 in vivo or in vitro, and...
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Source: Cancer Weekly (2004-12-07)
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