Published in Cancer Weekly, December 7th, 2004
According to a study from Germany, "The display of recombinant antibody fragments on the surface of filamentous phage mimics B cells and is therefore a technology ideal to generate antibodies against any potential target antigen in vitro. In order to obtain tumor specific, high-affinity single chain antibody fragments (scFv), it has been speculated that lymph node tissue from cancer patients infiltrated with activated B cells must be a valuable source of antibody V-genes. The aim of this study was to generate a human scFv-phage library from lymph nodes of...
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