Breast Cancer

Phage display library from lymph nodes of breast cancer patients constructed

Published in Cancer Weekly, December 7th, 2004

Researchers have constructed phage display libraries from reactive lymph nodes of breast carcinoma patients.

According to a study from Germany, "The display of recombinant antibody fragments on the surface of filamentous phage mimics B cells and is therefore a technology ideal to generate antibodies against any potential target antigen in vitro. In order to obtain tumor specific, high-affinity single chain antibody fragments (scFv), it has been speculated that lymph node tissue from cancer patients infiltrated with activated B cells must be a valuable source of antibody V-genes. The aim of this study was to generate a human scFv-phage library from lymph nodes of...

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Source: Cancer Weekly (2004-12-07)

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