Cancer Vaccines
Interleukin-15 transfection plus CD8+ T cells cause colon cancer rejection
Published in Cancer Weekly, December 7th, 2004
"Although interleukin (IL)-15 augments innate and acquired immunities, IL-15 expression is controlled at the levels of transcription, translation and intracellular trafficking. We constructed plasmid vectors encoding the murine mature-IL-15 cDNA linked to an Igkappa leader sequence and full-length murine IL-15 cDNA to evaluate the efficacy of the mature-IL-15 vector. Weakly immunogenic colon 26 cells were transfected with the above-mentioned vectors or with empty vector (mock)," researchers in Japan report.
"Transfectants with mature-IL-15 produced significantly higher levels...
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Source: Cancer Weekly (2004-12-07)
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