Breast Cancer

High geminin expression predicts adverse outcome in breast cancer patients

Published in Cancer Weekly, December 14th, 2004

Elevated geminin expression predicts adverse outcome in breast cancer patients.

"Geminin inhibits DNA replication by preventing Cdt1 from loading minichromosome maintenance (MCM) proteins onto DNA," according to pathologists in England, who "investigated whether the frequency of geminin expression predicts clinical outcome in breast cancer."

"Immunohistochemistry was used first to examine geminin expression in normal and malignant breast tissue (n=67)," noted M.A. Gonzalez and coauthors at the Hutchison/MRC Research Centre in Cambridge. "Correlations with cell-cycle parameters, pathological features, and clinical outcome were then determined using an...

Want to see the full article?

Purchase this article for only $3.00

We're a pay-per-view site for premium content. If you'd like to purchase this article, it's only $3.00.

Welcome to NewsRx!

Learn more about a six-week, no-risk free trial of Cancer Weekly

Source: Cancer Weekly (2004-12-14)

NewsRx is Social

Top Medical Newsletters

Awards

Best Health/Healthcare Content, 2012
Best Health/Healthcare Content, 2011
Best e-Business Site, 2010
Best e-Business Site, 2009
Best e-Business Site, 2008
Best e-Business Site, 2007
Best e-Business Site, 2006
Best Healthcare Content, 2005
Best Overall Internet Site, 2005
Best Interactive Site, 2005

Facts & Stats

NewsRx also is available at LexisNexis, Gale, ProQuest, Factiva, Dialog, Thomson Reuters, NewsEdge, and Dow Jones.

Google 2010 PageRank: #2 Among Top Health News and Media Publications
Google 2010 PageRank: #2 Among Top Science Publications in Biology/Physiology
Google 2010 PageRank: #2 Among Top News and Media for the Business of Pharmaceuticals
Amazon's Alexa 2010 PageRank: #2 News and Media Site for the Pharmaceutical Industry