Published in Cancer Weekly, December 14th, 2004
"Geminin inhibits DNA replication by preventing Cdt1 from loading minichromosome maintenance (MCM) proteins onto DNA," according to pathologists in England, who "investigated whether the frequency of geminin expression predicts clinical outcome in breast cancer."
"Immunohistochemistry was used first to examine geminin expression in normal and malignant breast tissue (n=67)," noted M.A. Gonzalez and coauthors at the Hutchison/MRC Research Centre in Cambridge. "Correlations with cell-cycle parameters, pathological features, and clinical outcome were then determined using an...
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