Published in Cancer Weekly, December 14th, 2004
According to a study from the United States, "Novel agents to treat acute myeloid leukemia (AML) are needed with increased efficacy and specificity.
"We have synthesized a dual-specificity fusion toxin DTU2GMCSF composed of the catalytic and translocation domains of diphtheria toxin (DT) fused to the granulocyte-macrophage colony-stimulating factor (GM-CSF) in which the DT furin cleavage site 163RVRRSV170 is modified to a urokinase plasminogen activator (uPA) cleavage site (163)GSGRSA(170), termed U2."
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