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Cervical Cancer

FRA8C is involved in HPV integration and chromosomal translocations

Published in Cancer Weekly, December 14th, 2004

According to a study from the Netherlands, "Molecular cytogenetic analysis frequently shows human papillomavirus (HPV) integration near translocation breakpoints in cervical cancer cells.

"We have recently described a cluster of HPV 18 integrations in the distal end of the common fragile site FRA8C at 8q24 in primary cervical carcinoma samples. Chromosome band 8q24 contains the MYC gene (alias c-MYC), FRA8C, and FRA8D. The MYC gene is frequently deregulated - usually by translocation or amplification - in various tumor types," said M.J. Ferber, Vrije University of Amsterdam, and colleagues.

In their current study, published in Cancer Genetics and...

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